Construction of Methotrexate-Loaded Bi2S3 Coated with Fe/Mn-Bimetallic Doped ZIF-8 Nanocomposites for Cancer Treatment Through the Synergistic Effects of Photothermal/Chemodynamic/Chemotherapy DOI Creative Commons
Pranjyan Dash, Nandini Nataraj, Pradeep Kumar Panda

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 17(1), P. 222 - 234

Published: Oct. 17, 2024

A combination of therapeutic modalities in a single nanostructure is crucial for successful cancer treatment. Synergistic photothermal therapy (PTT) can enhance the effects chemodynamic (CDT) and chemotherapy, which could intensify efficacy to induce cell apoptosis. In this study, Fe Mn on zeolitic imidazolate framework (ZIF-8) (Fe/Mn-ZIF-8; FMZ) were synthesized through ion deposition. Furthermore, bismuth sulfide nanorods (Bi2S3 NRs; BS NRs) via hydrothermal process coated onto FMZ generate core-shell structure Bi2S3@FMZ nanoparticles (B@FMZ). Next, methotrexate (MTX) was loaded effectively porous surface ZIF-8 form B@FMZ/MTX nanoparticles. The Fenton-like reaction catalyzes Fe2+/Mn2+ ions by decomposing H2O2 tumor microenvironment, resulting formation toxic hydroxyl radicals (·OH), promotes CDT effect killing cells. under 808 nm laser irradiation, these B@FMZ showed strong PTT effect, owing presence intense NRs as agent. exhibited prominent drug release efficiency 87.25% at pH 5.5 near-infrared irradiation due promote delivery performance. subjected dual-modal imaging, guided magnetic resonance X-ray computed tomography imaging. Both vitro vivo results suggested that enhanced antitumor combined PTT, CDT, chemotherapy. Therefore, exhibit good biocompatibility are promising candidates

Language: Английский

Multifunctional porous organic polymer-based hybrid nanoparticles for sonodynamically enhanced cuproptosis and synergistic tumor therapy DOI
Meiting Li,

Zhuoyin Liu,

Dan Peng

et al.

Acta Biomaterialia, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Citations

0
A ZIF-8 nano drug delivery system that inhibits protective autophagy in cancer cells for enhancing photothermal antitumor therapy DOI

Yu Sun,

Jianfang Cen,

Liyun Yang

et al.

Journal of Drug Delivery Science and Technology, Journal Year: 2025, Volume and Issue: unknown, P. 106954 - 106954

Published: April 1, 2025

Language: Английский

Citations

0
Construction of Methotrexate-Loaded Bi2S3 Coated with Fe/Mn-Bimetallic Doped ZIF-8 Nanocomposites for Cancer Treatment Through the Synergistic Effects of Photothermal/Chemodynamic/Chemotherapy DOI Creative Commons
Pranjyan Dash, Nandini Nataraj, Pradeep Kumar Panda

et al.

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 17(1), P. 222 - 234

Published: Oct. 17, 2024

A combination of therapeutic modalities in a single nanostructure is crucial for successful cancer treatment. Synergistic photothermal therapy (PTT) can enhance the effects chemodynamic (CDT) and chemotherapy, which could intensify efficacy to induce cell apoptosis. In this study, Fe Mn on zeolitic imidazolate framework (ZIF-8) (Fe/Mn-ZIF-8; FMZ) were synthesized through ion deposition. Furthermore, bismuth sulfide nanorods (Bi2S3 NRs; BS NRs) via hydrothermal process coated onto FMZ generate core-shell structure Bi2S3@FMZ nanoparticles (B@FMZ). Next, methotrexate (MTX) was loaded effectively porous surface ZIF-8 form B@FMZ/MTX nanoparticles. The Fenton-like reaction catalyzes Fe2+/Mn2+ ions by decomposing H2O2 tumor microenvironment, resulting formation toxic hydroxyl radicals (·OH), promotes CDT effect killing cells. under 808 nm laser irradiation, these B@FMZ showed strong PTT effect, owing presence intense NRs as agent. exhibited prominent drug release efficiency 87.25% at pH 5.5 near-infrared irradiation due promote delivery performance. subjected dual-modal imaging, guided magnetic resonance X-ray computed tomography imaging. Both vitro vivo results suggested that enhanced antitumor combined PTT, CDT, chemotherapy. Therefore, exhibit good biocompatibility are promising candidates

Language: Английский

Citations

1