Nanotherapeutics induced redox resetting of oxidative and nitrosative stress: targeting glutathione-depletion in cancer DOI

Kapil Dangi,

Vijay Kumar, Disha Mittal

et al.

Nanomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 11

Published: April 7, 2025

Cancer cells display a distinctive defense mechanism against any exogenous moieties that renders all treatments inefficient. Glutathione, thiol tripeptide plays paradoxical role in cancer as intracellular glutathione (GSH) are voracious scavengers of free radicals produced by chemotherapy, generation reactive oxygen species (ROS) and nitrogen (RNS). show Warburg effect, wherein the GSH levels exceptionally enhanced to overcome oxidative stress created ROS/RNS production or other generated side products redox reactions. Therefore, resetting is essential maintain homeostasis for cell survival their proliferation trigger escalation levels. Nanotherapeutics have facilitated targeted delivery GSH-depleting agents combination with radiotherapy, novel therapeutic interventions including chemodynamic therapy (CDT), photodynamic (PDT), ferroptosis induction, sonodynamic (SDT), immunotherapy being explored. This review aims compile strategic cells, importance nanotherapeutics depletion target numerous forms programmed death (PCD), apoptosis, ferroptosis, necroptosis, autophagy.

Language: Английский

Nanotherapeutics induced redox resetting of oxidative and nitrosative stress: targeting glutathione-depletion in cancer DOI

Kapil Dangi,

Vijay Kumar, Disha Mittal

et al.

Nanomedicine, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 11

Published: April 7, 2025

Cancer cells display a distinctive defense mechanism against any exogenous moieties that renders all treatments inefficient. Glutathione, thiol tripeptide plays paradoxical role in cancer as intracellular glutathione (GSH) are voracious scavengers of free radicals produced by chemotherapy, generation reactive oxygen species (ROS) and nitrogen (RNS). show Warburg effect, wherein the GSH levels exceptionally enhanced to overcome oxidative stress created ROS/RNS production or other generated side products redox reactions. Therefore, resetting is essential maintain homeostasis for cell survival their proliferation trigger escalation levels. Nanotherapeutics have facilitated targeted delivery GSH-depleting agents combination with radiotherapy, novel therapeutic interventions including chemodynamic therapy (CDT), photodynamic (PDT), ferroptosis induction, sonodynamic (SDT), immunotherapy being explored. This review aims compile strategic cells, importance nanotherapeutics depletion target numerous forms programmed death (PCD), apoptosis, ferroptosis, necroptosis, autophagy.

Language: Английский

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