AuCu@CuO2 Aerogels with H2O2/O2 Self‐Supplying and Quadruple Enzyme‐Like Activity for MRSA‐Infected Diabetic Wound Management DOI Creative Commons
Xiaofeng Tan,

Nanyun Lin,

Sha Yang

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 27, 2025

Abstract Diabetic wound healing presents serious clinical challenges due to the unique microenvironment characterized by hyperglycemia, bacterial infection, excessive oxidative stress, and hypoxia. Herein, a copper peroxide (CuO 2 )‐coated AuCu bimetallic aerogel is developed that exhibits quadruple enzyme‐mimicking activity H O /O self‐supplying modulate complex of methicillin‐resistant staphylococcus aureus (MRSA) ‐infected diabetic wounds. The AuCu@CuO aerogels demonstrate favorable photothermal properties mimic four enzyme‐like activities: peroxidase‐like for producing toxic reactive oxygen species; catalase‐like decomposing release relieve stress hypoxia; glucose oxidase‐like reducing blood glutathione balancing abnormal level. CuO coating facilitates continuous adequate in situ production within mildly acidic infection microenvironment, enabling excellent antibacterial reduced levels during initial treatment infected Furthermore, engineered not only scavenge elevated ROS inflammatory phase but also synergistically generate promote healing. Overall, aerogelsmicroenvironment can be activated microenvironments, alleviating inflammation, hypoxia, lowering levels, enhancing angiogenesis collagen fiber accumulation, thereby significantly improving

Language: Английский

AuCu@CuO2 Aerogels with H2O2/O2 Self‐Supplying and Quadruple Enzyme‐Like Activity for MRSA‐Infected Diabetic Wound Management DOI Creative Commons
Xiaofeng Tan,

Nanyun Lin,

Sha Yang

et al.

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 27, 2025

Abstract Diabetic wound healing presents serious clinical challenges due to the unique microenvironment characterized by hyperglycemia, bacterial infection, excessive oxidative stress, and hypoxia. Herein, a copper peroxide (CuO 2 )‐coated AuCu bimetallic aerogel is developed that exhibits quadruple enzyme‐mimicking activity H O /O self‐supplying modulate complex of methicillin‐resistant staphylococcus aureus (MRSA) ‐infected diabetic wounds. The AuCu@CuO aerogels demonstrate favorable photothermal properties mimic four enzyme‐like activities: peroxidase‐like for producing toxic reactive oxygen species; catalase‐like decomposing release relieve stress hypoxia; glucose oxidase‐like reducing blood glutathione balancing abnormal level. CuO coating facilitates continuous adequate in situ production within mildly acidic infection microenvironment, enabling excellent antibacterial reduced levels during initial treatment infected Furthermore, engineered not only scavenge elevated ROS inflammatory phase but also synergistically generate promote healing. Overall, aerogelsmicroenvironment can be activated microenvironments, alleviating inflammation, hypoxia, lowering levels, enhancing angiogenesis collagen fiber accumulation, thereby significantly improving

Language: Английский

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