Emerging Piezoelectric Metamaterials for Biomedical Applications DOI Creative Commons

Zishuo Yan,

Huy Quang Tran, Dongxin Ma

et al.

Published: Nov. 21, 2024

Emerging piezoelectric metamaterials hold immense promise for biomedical applications by merging the intrinsic electrical properties of piezoelectricity with precise architecture metamaterials. This review provides a comprehensive overview various materials- such as molecular crystals, ceramics, and polymers-known their exceptional performance biocompatibility. We explore advanced engineering approaches, including design, supramolecular packing, 3D assembly, which enable customization targeted applications. Particular attention is given to pivotal role metamaterial structuring in development 0D spheres, 1D fibers tubes, 2D films, scaffolds. Key applications, tissue engineering, drug delivery, wound healing, biosensing, are discussed through illustrative examples. Finally, article addresses critical challenges future directions, aiming drive further innovations biomaterials next-generation healthcare technologies.

Language: Английский

Superior Ductile and Barrier PLA/PGA Films by an In Situ Constructing Transversely Isotropic Network and Well-Ordered Crystalline Nanolayers DOI
Bo Liu, Pengwu Xu,

Deyu Niu

et al.

Macromolecules, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 9, 2025

Simultaneously achieving excellent toughness, transparency, and gas barrier properties is still a challenge for poly(lactic acid) (PLA) films. In this work, we address an effective scalable strategy based on biaxial stretching to make superior ductile, transparent, high-barrier PLA films by incorporating polyglycolic acid (PGA) constructing transversely isotropic structure in the matrix with numerous nanocrystals nanolayer PGA phase. The endowed PLA/PGA robust chain entanglement network, which prevents formation of densely distributed cohesional physical aging PLA, allowing molecular chains move sufficiently exhibit toughness. Consequently, tensile strength film increased from 67 157 MPa while maintaining high elongation at break (>100%), transparency (>85%), durability, demonstrating comprehensive mechanical properties. Importantly, situ constructed phase greatly prolongs diffusion path molecules films, consequently oxygen permeability coefficient (PO2) decreased almost two orders magnitude, i.e., 1.66 × 10–14 7.10 10–16 cm3·cm/cm2·s·Pa, compared that neat three magnitude lower than polyethylene film. Therefore, work contributes deeper understanding structure–property relationship biaxially oriented PLA-based may enable their application green packaging field.

Language: Английский

Citations

3
Flexible and Robust Piezoelectric Chitosan Films with Enhanced Bioactivity DOI

Srishti Chakraborty,

Souvik Debnath, Kailas Mahipal Malappuram

et al.

Biomacromolecules, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 13, 2025

Chitosan (CHT) is a known piezoelectric biomacromolecule; however, its usage limited due to rapid degradation in an aqueous system. Herein, we prepared CHT film via solvent casting method and cross-linked alkaline solution. Sodium hydroxide facilitated deprotonation, leading increased intramolecular hydrogen bonding mechanical properties. The remained intact for 30 days environments. A systematic study revealed gradual increase the output voltage from 0.9 1.8 V under external force (1-16 N). In addition, showed remarkable antibacterial anti-inflammatory activities ultrasound stimulation inhibition of inflammatory cytokines. films also displayed enhanced cellular proliferation ∼5-fold faster migration NIH3T3 cells US stimulation. Overall, this work presents robust, biocompatible, wearable device that can transform biomechanical energy into electrical pulses modulation cell fate processes other bioactivities.

Language: Английский

Citations

0
Biodegradable Piezoelectric Micro‐ and Nanomaterials for Regenerative Medicine, Targeted Therapy, and Microrobotics DOI Creative Commons
Lorenzo Vannozzi, Carlotta Pucci, Diego Trucco

et al.

Small Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

Piezoelectric micro‐ and nanomaterials can generate local electrical signals when subjected to mechanical stress, a phenomenon that be exploited trigger beneficial effects at the cell tissue level. In recent years, research on biodegradable piezoelectric material has gained momentum, as these materials degrade after fulfilling their function. Thus, they promise considerably impact regenerative medicine, targeted therapy, microrobotics, with better chances match regulatory requirements respect nondegradable counterparts. This review offers comprehensive overview of advancements in nanomaterials, focusing mechanisms, types, methods enhance properties. Current characterization techniques, emphasizing both piezoelectricity biodegradability micro/nano scale, are also discussed. Furthermore, it is discussed how use intelligent platforms for medicine responsive drug delivery systems. The application microrobotics examined, particularly potential minimally invasive procedures. Finally, challenges future directions highlighted, underscoring importance versatile advancing biomedical technologies.

Language: Английский

Citations

0
Recent progress in 3D printed piezoelectric materials for biomedical applications DOI
Muhammad Hamza, Qudsia Kanwal, M. Irfan Hussain

et al.

Materials Science and Engineering R Reports, Journal Year: 2025, Volume and Issue: 164, P. 100962 - 100962

Published: March 6, 2025

Language: Английский

Citations

0
Key factors affecting the piezoelectric response of poly-L-lactic acid electrospun fibers DOI
Christian Rentero, Harvey Amorín, Ricardo Jiménez

et al.

Polymer, Journal Year: 2025, Volume and Issue: unknown, P. 128286 - 128286

Published: March 1, 2025

Language: Английский

Citations

0
Piezoelectric poly-L-lactic acid for next-generation energy harvesting and biomedical applications DOI

Menghan Xu,

Yongxian Wen,

Donghui Li

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 162536 - 162536

Published: April 1, 2025

Language: Английский

Citations

0
Tailorable Piezoelectric Chain Morphology in Biocompatible Poly-l-lactide Induced by Melt-Based 3D Printing DOI Creative Commons
Cristina Pascual-González,

Gustavo Pacheco-Carpio,

Juan P. Fernandéz‐Blázquez

et al.

ACS Applied Polymer Materials, Journal Year: 2025, Volume and Issue: unknown

Published: May 6, 2025

Language: Английский

Citations

0
Applications of Piezoelectric Biomaterials in Dental Treatments: A Review of Recent Advancements and Future Prospects DOI Creative Commons

Kaichen Zeng,

Yifan Lin, Shi-Rong Liu

et al.

Materials Today Bio, Journal Year: 2024, Volume and Issue: 29, P. 101288 - 101288

Published: Oct. 4, 2024

Language: Английский

Citations

3
Emerging Piezoelectric Metamaterials for Biomedical Applications DOI Creative Commons

Zishuo Yan,

Huy Quang Tran, Dongxin Ma

et al.

Published: Nov. 21, 2024

Emerging piezoelectric metamaterials hold immense promise for biomedical applications by merging the intrinsic electrical properties of piezoelectricity with precise architecture metamaterials. This review provides a comprehensive overview various materials- such as molecular crystals, ceramics, and polymers-known their exceptional performance biocompatibility. We explore advanced engineering approaches, including design, supramolecular packing, 3D assembly, which enable customization targeted applications. Particular attention is given to pivotal role metamaterial structuring in development 0D spheres, 1D fibers tubes, 2D films, scaffolds. Key applications, tissue engineering, drug delivery, wound healing, biosensing, are discussed through illustrative examples. Finally, article addresses critical challenges future directions, aiming drive further innovations biomaterials next-generation healthcare technologies.

Language: Английский

Citations

3