Supramolecular Gels for Antimicrobial Photodynamic Therapy against E. coli and S. aureus DOI Creative Commons

Kavya Anguluri,

Bunty Sharma, Saman Bagherpour

et al.

Photodiagnosis and Photodynamic Therapy, Journal Year: 2025, Volume and Issue: 52, P. 104529 - 104529

Published: Feb. 22, 2025

Singlet oxygen (SO) reacts with organic molecules, for example in degrading environmental contaminants and causing toxicity to cells photodynamic therapy (PDT). The relevance of SO the biomedical domains has fuelled research towards improved methodologies its efficient generation. In this paper, we report use a bis-imidazolium-based amphiphile that forms supramolecular gels water-ethanol mixtures encapsulating generating chromophores. comprise twisted fibres incorporate one four different porphyrins: 5,10,15,20-tetrakis(N-methyl-4-pyridinium)porphyrin tetraiodide (TPPP), 5,10,15,20-tetrakis(4-carboxyphenyl)porphyrin (TCPP), 5,10,15,20-tetrakis(3-hydroxyphenyl)porphyrin (TPP-3OH) 5,10,15,20-tetrakis(4-hydroxyphenyl)porphyrin (TPP-4OH). Rheological measurements confirmed viscoelastic properties characteristic these types gels, suggesting their potential as effective local PDT delivery systems. Enhanced generation within hydrogel matrix compared solution chromophores was observed suspension spectrophotometer using uric acid molecular probe. also shown through antimicrobial (aPDT) studies. TPPP-containing gel showed highest reduction colony forming unit (CFU) count, which is 94% against E. coli 100% S. aureus. These results indicate porphyrin based on gemini high level production are significant interest have lot aPDT.

Language: Английский

Supramolecular Gels for Antimicrobial Photodynamic Therapy against E. coli and S. aureus DOI Creative Commons

Kavya Anguluri,

Bunty Sharma, Saman Bagherpour

et al.

Photodiagnosis and Photodynamic Therapy, Journal Year: 2025, Volume and Issue: 52, P. 104529 - 104529

Published: Feb. 22, 2025

Singlet oxygen (SO) reacts with organic molecules, for example in degrading environmental contaminants and causing toxicity to cells photodynamic therapy (PDT). The relevance of SO the biomedical domains has fuelled research towards improved methodologies its efficient generation. In this paper, we report use a bis-imidazolium-based amphiphile that forms supramolecular gels water-ethanol mixtures encapsulating generating chromophores. comprise twisted fibres incorporate one four different porphyrins: 5,10,15,20-tetrakis(N-methyl-4-pyridinium)porphyrin tetraiodide (TPPP), 5,10,15,20-tetrakis(4-carboxyphenyl)porphyrin (TCPP), 5,10,15,20-tetrakis(3-hydroxyphenyl)porphyrin (TPP-3OH) 5,10,15,20-tetrakis(4-hydroxyphenyl)porphyrin (TPP-4OH). Rheological measurements confirmed viscoelastic properties characteristic these types gels, suggesting their potential as effective local PDT delivery systems. Enhanced generation within hydrogel matrix compared solution chromophores was observed suspension spectrophotometer using uric acid molecular probe. also shown through antimicrobial (aPDT) studies. TPPP-containing gel showed highest reduction colony forming unit (CFU) count, which is 94% against E. coli 100% S. aureus. These results indicate porphyrin based on gemini high level production are significant interest have lot aPDT.

Language: Английский

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