An overview of recent advancements in 4D printing of alginate hydrogels for tissue regeneration
Y. Liu,
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Aixiang Ding
No information about this author
Journal of Biomaterials Science Polymer Edition,
Journal Year:
2025,
Volume and Issue:
unknown, P. 1 - 34
Published: May 24, 2025
4D
printing
of
alginate
hydrogels
has
emerged
as
a
transformative
strategy
in
tissue
engineering,
enabling
the
fabrication
stimuli-responsive
scaffolds
that
recapitulate
temporal
and
spatial
complexities
native
tissues.
Leveraging
alginate's
tunable
crosslinking,
biocompatibility,
easy
modification,
recent
research
demonstrated
successful
design
constructs
capable
programmable
shape
morphing
response
to
physiological
stimuli.
This
review
highlights
advances
polymer
design,
including
methacrylated,
oxidized,
ligand-functionalized
derivatives,
cutting-edge
technologies
such
extrusion-based
photopolymerization-based
technologies.
Notably,
these
systems
have
shown
promising
outcomes
regenerating
cartilage,
bone,
vascular,
neural
However,
key
challenges
remain,
standardization
shape-morphing
quantification,
enhancement
mechanical
robustness,
improvement
host
integration,
replication
complexity.
concludes
with
critical
evaluation
current
limitations
future
directions,
highlighting
potential
integrating
hydrogel
emerging
artificial
intelligence,
machine
learning,
organoid
models,
bioelectronic
interfaces
accelerate
innovation
broaden
their
application
engineering.
By
synthesizing
advancements
offering
insights
into
implementation
hydrogels,
this
aims
stimulate
continued
progress
rapidly
evolving
field.
Language: Английский
Hydrogel-Based Continuum Soft Robots
Gels,
Journal Year:
2025,
Volume and Issue:
11(4), P. 254 - 254
Published: March 27, 2025
This
paper
comprehensively
reviews
the
latest
advances
in
hydrogel-based
continuum
soft
robots.
Hydrogels
exhibit
exceptional
flexibility
and
adaptability
compared
to
traditional
robots
reliant
on
rigid
structures,
making
them
ideal
as
biomimetic
robotic
skins
platforms
for
constructing
highly
accurate,
real-time
responsive
sensory
interfaces.
The
article
systematically
summarizes
recent
research
developments
across
several
key
dimensions,
including
application
domains,
fabrication
methods,
actuator
technologies,
sensing
mechanisms.
From
an
perspective,
span
healthcare,
manufacturing,
agriculture.
Regarding
techniques,
extensively
explores
crosslinking
additive
microfluidics,
other
related
processes.
Additionally,
categorizes
thoroughly
discusses
various
actuators
solute/solvent
variations,
pH,
chemical
reactions,
temperature,
light,
magnetic
fields,
electric
hydraulic/electro-osmotic
stimuli,
humidity.
It
also
details
strategies
designing
implementing
diverse
sensors,
strain,
pressure,
humidity,
conductive,
magnetic,
thermal,
gas,
optical,
multimodal
sensors.
Finally,
offers
in-depth
discussion
of
prospective
applications
robots,
particularly
emphasizing
their
potential
medical
industrial
fields.
Concluding
remarks
include
a
forward-looking
outlook
highlighting
future
challenges
promising
directions.
Language: Английский
A 3D‐dynamic networks strategy utilizing SiO2‐nanoscale ionic materials in novel waterborne polyurethane ionic nanocomposites for fast self‐healing and UV‐blocking performance
Polymer Composites,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 29, 2025
Abstract
Waterborne
polyurethane
(WPU)
is
one
of
the
most
applicable
products
used
in
various
industries
to
manufacture
smart
coatings
with
self‐healing
ability
due
its
being
environmentally
friendly.
However,
self‐healable
WPU
suffer
from
long
healing
times,
low
transparency,
and
poor
physicochemical
properties.
Herein,
ionic
nanocomposite
were
prepared
based
on
SiO
2
‐nanoscale
materials
(SiO
‐NIMs)
novel
WPU,
fast
ability,
high
UV‐blocking
performance.
We
demonstrate
that
‐NIMs
can
significantly
act
as
a
unique
agent
their
fluid
3D‐dynamic
networks
hard
core‐corona
‐SO
3
−
)
soft
segments
(canopy).
The
optical
micrographs
show
film
containing
phr
completely
repaired
after
20
min
at
50°C.
tensile
test
illustrates
elongation
break,
strength,
toughness
values
healed
sample
recovered
78.2%,
94.2%,
69.3%
original
film,
respectively.
differential
scanning
calorimetry,
x‐ray
diffraction,
dynamic
mechanical‐thermal
tests
applied
confirm
core‐corona‐canopy
segments'
hardening
excellent
damping
behavior
matrix.
thermogravimetric
analyses
enhance
thermal
stability
mechanical
properties
WPU.
This
study
introduces
strategy
for
preparing
polymers
outstanding
Highlights
Synthesized
anionic
Congo
red.
Introducing
strategy‐based
coatings.
Enhancement
thermo‐mechanical
healable
abilities
coating.
Language: Английский
4D Printing of Thermoresponsive OEGMA‐Based Hydrogels with Tunable Response
Macromolecular Materials and Engineering,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 7, 2025
Abstract
Hydrogels,
particularly
those
exhibiting
responsive
behaviors,
have
gained
significant
attention,
especially
with
the
advent
of
4D
printing.
Among
thermoresponsive
hydrogels,
poly(
N
‐isopropylacrylamide)
(PNIPAM)‐based
materials
remain
a
benchmark
for
microprinting,
featuring
typical
lower
critical
solution
temperatures
(LCSTs)
ranging
from
32
to
37
°C.
However,
precise
tuning
LCST
broader
temperature
range
is
necessary
expand
application
window.
This
study
introduces
poly(oligo(ethylene
glycol)methacrylate)
(POEGMA)‐based
polymers
as
alternative
two‐photon
laser
printing
(2PLP).
First,
library
prepolymers
LCSTs
33
66
°C
synthesized
and
characterized.
By
formulating
these
suitable
photoinitiator
in
water,
inks
compatible
2PLP
are
created.
The
performance
each
ink
evaluated
by
fabricating
complex
microstructures,
including
various
platonic
solids
°C,
surpassing
constraints
PNIPAM.
actuation
material
quantitatively
monitoring
volume
changes
at
different
temperatures.
Finally,
arrays
“twistable”
tetrahedrons
fabricated
employing
designed
materials,
showcasing
temperature‐selective
actuation.
Thus,
it
demonstrated
that
careful
design
macromolecular
architecture
offers
adjustment
final
printed
feature
highly
beneficial
applications
like
soft
microrobotics
among
others.
Language: Английский