Macromolecular Bioscience,
Journal Year:
2024,
Volume and Issue:
24(6)
Published: March 28, 2024
Abstract
Spinal
cord
injury,
traumatic
brain
and
neurosurgery
procedures
usually
lead
to
neural
tissue
damage.
Self‐assembled
peptide
(SAP)
hydrogels,
a
type
of
innovative
hierarchical
nanofiber‐forming
sequences
serving
as
hydrogelators,
have
emerged
promising
solution
for
repairing
defects
promoting
regeneration.
SAPs
possess
numerous
features,
such
adaptable
morphologies,
biocompatibility,
injectability,
tunable
mechanical
stability,
mimicking
the
native
extracellular
matrix.
This
review
explores
capacity
cell
regeneration
examines
critical
aspects
in
neuroregeneration,
including
their
biochemical
composition,
topology,
behavior,
conductivity,
degradability.
Additionally,
it
delves
into
latest
strategies
involving
central
or
peripheral
engineering.
Finally,
prospects
SAP
hydrogel
design
development
realm
neuroregeneration
are
discussed.
Pharmaceutics,
Journal Year:
2023,
Volume and Issue:
15(6), P. 1750 - 1750
Published: June 16, 2023
Neural
tissue
engineering
presents
a
compelling
technological
breakthrough
in
restoring
brain
function,
holding
immense
promise.
However,
the
quest
to
develop
implantable
scaffolds
for
neural
culture
that
fulfill
all
necessary
criteria
poses
remarkable
challenge
material
science.
These
materials
must
possess
host
of
desirable
characteristics,
including
support
cellular
survival,
proliferation,
and
neuronal
migration
minimization
inflammatory
responses.
Moreover,
they
should
facilitate
electrochemical
cell
communication,
display
mechanical
properties
akin
brain,
emulate
intricate
architecture
extracellular
matrix,
ideally
allow
controlled
release
substances.
This
comprehensive
review
delves
into
primary
requisites,
limitations,
prospective
avenues
scaffold
design
engineering.
By
offering
panoramic
overview,
our
work
aims
serve
as
an
essential
resource,
guiding
creation
endowed
with
bio-mimetic
properties,
ultimately
revolutionizing
treatment
neurological
disorders
by
developing
brain-implantable
scaffolds.
Biosensors,
Journal Year:
2023,
Volume and Issue:
13(8), P. 815 - 815
Published: Aug. 14, 2023
Hydrogels
are
considered
an
ideal
platform
for
personalized
healthcare
due
to
their
unique
characteristics,
such
as
outstanding
softness,
appealing
biocompatibility,
excellent
mechanical
properties,
etc.
Owing
the
high
similarity
between
hydrogels
and
biological
tissues,
have
emerged
a
promising
material
candidate
next
generation
bioelectronic
interfaces.
In
this
review,
we
discuss
(i)
introduction
of
hydrogel
its
traditional
applications,
(ii)
work
principles
in
bioelectronics,
(iii)
recent
advances
bioelectronics
health
monitoring,
(iv)
outlook
future
bioelectronics'
development.
Cells,
Journal Year:
2024,
Volume and Issue:
13(10), P. 855 - 855
Published: May 17, 2024
Cardiovascular
diseases
continue
to
challenge
global
health,
demanding
innovative
therapeutic
solutions.
This
review
delves
into
the
transformative
role
of
mesenchymal
stem
cells
(MSCs)
in
advancing
cardiovascular
therapeutics.
Beginning
with
a
historical
perspective,
we
trace
development
cell
research
related
diseases,
highlighting
foundational
approaches
and
evolution
cell-based
treatments.
Recognizing
inherent
challenges
MSC-based
therapeutics,
which
range
from
understanding
pro-reparative
activity
MSCs
tailoring
patient-specific
treatments,
emphasize
need
refine
pro-regenerative
capacity
these
cells.
Crucially,
our
focus
then
shifts
strategies
fourth
generation
therapies:
leveraging
secretomic
prowess
MSCs,
particularly
extracellular
vesicles;
integrating
biocompatible
scaffolds
artificial
sheets
amplify
MSCs’
potential;
adopting
three-dimensional
ex
vivo
propagation
tailored
specific
tissue
niches;
harnessing
promise
genetic
modifications
for
targeted
repair;
institutionalizing
good
manufacturing
practice
protocols
ensure
safety
efficacy.
We
conclude
reflections
on
advancements,
envisaging
future
landscape
redefined
by
regeneration.
offers
both
consolidation
current
view
toward
imminent
horizons.
Macromolecular Bioscience,
Journal Year:
2024,
Volume and Issue:
24(6)
Published: March 28, 2024
Abstract
Spinal
cord
injury,
traumatic
brain
and
neurosurgery
procedures
usually
lead
to
neural
tissue
damage.
Self‐assembled
peptide
(SAP)
hydrogels,
a
type
of
innovative
hierarchical
nanofiber‐forming
sequences
serving
as
hydrogelators,
have
emerged
promising
solution
for
repairing
defects
promoting
regeneration.
SAPs
possess
numerous
features,
such
adaptable
morphologies,
biocompatibility,
injectability,
tunable
mechanical
stability,
mimicking
the
native
extracellular
matrix.
This
review
explores
capacity
cell
regeneration
examines
critical
aspects
in
neuroregeneration,
including
their
biochemical
composition,
topology,
behavior,
conductivity,
degradability.
Additionally,
it
delves
into
latest
strategies
involving
central
or
peripheral
engineering.
Finally,
prospects
SAP
hydrogel
design
development
realm
neuroregeneration
are
discussed.
