Synergistic anti-inflammatory effects of curcumin and ginger oil: A potential alternative to steroid therapy

South African Journal of Botany, Journal Year: 2025, Volume and Issue: 180, P. 369 - 377

Published: March 21, 2025

Language: Английский

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Streptococcus salivarius subsp. thermophilus ST-G30 Prevents Dexamethasone-Induced Muscle Atrophy in C2C12 Myotubes

Nutrients, Journal Year: 2025, Volume and Issue: 17(7), P. 1141 - 1141

Published: March 26, 2025

Background/Objectives: Sarcopenia is characterized by loss of muscle mass and strength associated with aging. Recently, its links the gut-muscle axis have been reported, suggesting that probiotics could influence health. Methods: In present study, we investigated protective roles two lactic acid bacteria strains, Streptococcus salivarius subsp. thermophilus ST-G30 (ST-G30) Lacticaseibacillus paracasei LPc-G110 (LPc-G110), on skeletal atrophy induced dexamethasone (DEX) in C2C12 myotubes. Results: Our results demonstrated significantly alleviated DEX-induced myotube increasing myotubes' diameter (25.95 ± 1.28 vs. 15.30 0.30 μm, p < 0.01), improving fusion index (48.35 1.75 22.16 2.36%, 0.0001), protein content (1.78 0.02 1.56 0.01 mg/mL, 0.05) length (0.61 0.05 0.33 0.01, 0.05), whereas showed no significant effect these phenotypes (p > 0.05). Transcriptomic analysis reveals modulates critical signaling pathways biological processes related to current KEGG enrichment WGCNA enabled identification PI3K-Akt pathway as a key regulator processes, highlighting essential role mitigating atrophy. Furthermore, overlapping DEGs strong correlations atrophy-related indices. Conclusions: These findings underscore potential promising anti-muscle supplement provide valuable insights for developing strategies prevent treat glucocorticoid-induced

Language: Английский

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An engineering-reinforced extracellular vesicle–integrated hydrogel with an ROS-responsive release pattern mitigates spinal cord injury

Science Advances, Journal Year: 2025, Volume and Issue: 11(14)

Published: April 2, 2025

The local delivery of mesenchymal stem cell–derived extracellular vesicles (EVs) via hydrogel has emerged as an effective approach for spinal cord injury (SCI) treatment. However, achieving on-demand release EVs from to address dynamically changing pathology remains challenging. Here, we used a series engineering methods further enhance EVs’ efficacy and optimize their pattern hydrogel. Specifically, the pro-angiogenic, neurotrophic, anti-inflammatory effects were reinforced through three-dimensional culture dexamethasone (Dxm) encapsulation. Then, prepared Dxm-loaded 3EVs (3EVs-Dxm) membrane modified with ortho-dihydroxy groups (-2OH) formed EV-integrated (3EVs-Dxm-Gel) cross-link phenylboronic acid–modified hyaluronic acid tannic acid. ester in 3EVs-Dxm-Gel enabled immobilization reactive oxygen species–responsive EVs. Topical injection SCI rats notably mitigated severity promoted functional recovery, which may offer opportunities EV-based therapeutics central nervous system injury.

Language: Английский

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Influence of Perioperative Dexamethasone on the Delayed Union in Mandibular Fractures

Indus journal of bioscience research., Journal Year: 2025, Volume and Issue: 3(3), P. 678 - 687

Published: March 31, 2025

Background: Mandibular fractures are considered to be one of the most frequent facial bone which occur due trauma that causes functional, as well aesthetic, impairment. Perioperative use dexamethasone is associated with postoperative inflammation and pain control its effects a potent glucocorticosteroid. However, has been reported have an impact on healing, thus posing threat when used in treatment regimens because it likely slow fracture union rate. Objective: The purpose this case study determine effect perioperative causing delayed patients treated by surgical management mandibular fractures. Study design setting: A prospective cohort was conducted at Department Oral & Maxillofacial Surgery, Jinnah Postgraduate Medical Centre, Karachi from March 2024 September 2024. Methodology: 75 who were divided into two groups: One groups enrolled study, group receiving other acting group. Clinical radiographic examinations done different days or weeks after surgery evaluate healing status. Results: results obtained showed there higher incidence (26.3%) than (10.8%) longer mean time Conclusion: These indicated although can help minimize for limited amount time, will prejudicial considerably long term period especially high-risk category. Additional studies must how affects repair establish proper therapeutic strategies.

Language: Английский

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Nanofibers in Glioma Therapy: Advances, Applications, and Overcoming Challenges

International Journal of Nanomedicine, Journal Year: 2025, Volume and Issue: Volume 20, P. 4677 - 4703

Published: April 1, 2025

Despite relentless effort to study glioma treatment, the prognosis for patients remains poor. The main obstacles include high rate of recurrence and difficulty passing blood-brain barrier (BBB) therapeutic drugs. Nanomaterials owing their special physicochemical properties have been used in a wide range fields thus far. nanodrug delivery system (NDDS) with ability crossing BBB, targeting site, maintaining drug stability controlling release, has significantly enhanced anti-tumor effect, improving patients. Aligned nanofibers (NFs) are ideal materials establish vitro models microenvironment (GME), enabling exploration mechanism cell migration invasion discover novel targets. Moreover, NFs now widely applications such as radiotherapy, phototherapy, thermotherapy immunotherapy. absolute dominance anti-glioma applications, there still some problems further optimization NDDS, impact interactions between protein corona (PC) on therapy. This paper will shed light latest systems mimicking tumor (TME), discuss how optimize NDDS eliminate or utilize nanomedicine-PC interactions.

Language: Английский

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