International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 281, P. 136651 - 136651
Published: Oct. 19, 2024
Language: Английский
Journal of Drug Delivery Science and Technology, Journal Year: 2024, Volume and Issue: 97, P. 105770 - 105770
Published: May 11, 2024
Language: Английский
Citations
18
Discover Nano, Journal Year: 2024, Volume and Issue: 19(1)
Published: Aug. 5, 2024
Abstract Research into the anticancer activity of quantum-sized carbon dots (CDs) has emerged as a promising avenue in cancer research. This CDs delves opportunities and challenges associated with harnessing potential these nanostructures for combating cancer. Quantum-sized dots, owing to their unique physicochemical properties, exhibit distinct advantages therapeutic agents. Opportunities lie tunable size, surface functionalization capabilities, biocompatibility, enabling targeted drug delivery imaging cells. However, we include challenges, comprehensive understanding underlying mechanisms, toxicity concerns, optimization synthesis methods enhanced efficacy. A succinct summary state research this area is given review, emphasizing exciting possibilities ongoing utilizing novel strategy treatment.
Language: Английский
Citations
9
Biomedicine & Pharmacotherapy, Journal Year: 2024, Volume and Issue: 179, P. 117372 - 117372
Published: Aug. 28, 2024
Polymeric nanoparticles have emerged as promising contenders for addressing the intricate challenges encountered in brain tumor therapy due to their distinctive attributes, including adjustable size, biocompatibility, and controlled drug release kinetics. This review comprehensively delves into latest developments synthesizing, characterizing, applying polymeric explicitly tailored therapy. Various synthesis methodologies, such emulsion polymerization, nanoprecipitation, template-assisted fabrication, are scrutinized within context of targeting, elucidating advantages limitations concerning traversing blood-brain barrier. Furthermore, strategies pertaining surface modification functionalization expounded upon augment stability, targeting prowess amidst milieu microenvironment. Characterization techniques encompassing dynamic light scattering, transmission electron microscopy, spectroscopic methods evaluate physicochemical attributes engineered Moreover, a comprehensive exploration manifold applications delivery, gene therapy, imaging, combination therapies tumours is undertaken. Special emphasis placed on encapsulation diverse therapeutics nanoparticles, thereby shielding them from degradation enabling precise brain. Additionally, recent advancements stimuli-responsive multifunctional probed potential personalized medicine theranostics tumours. In essence, this furnishes an all-encompassing overview strides made tailoring illuminating synthesis, characterization, multifaceted application.
Language: Английский
Citations
5
Journal of Biomaterials Science Polymer Edition, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 48
Published: Jan. 2, 2025
Zein, a plant-based protein obtained from the endosperm of corn (
Language: Английский
Citations
0
Zeitschrift für Naturforschung C, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 7, 2025
Abstract The rising global population is a contributing factor to the exponential rise of agricultural output. Agro-wastes are now recognized as substitute substance produce sustainable, affordable, and renewable bio-based products. Abundant farm products due lack processing capacity or storage room frequently lost. A substantial amount biopolymer present in residues. It’s interesting that nanotechnology has potential more easily convert wastes into valuable affordable products, eliminating need use toxic chemicals, which can lead variety health environmental problems. Recently, there been interest environmentally beneficial carbon nanomaterial (CNM) manufacturing methods make waste extracts. Therefore, goal this review look various agro-waste sources, synthesis techniques CNMs, characterization methods, surface functionalization chemistry, mechanistic approach applications imaging crops, nutrient utilization, upgradation crop health.
Language: Английский
Citations
0
Cancer Treatment and Research Communications, Journal Year: 2025, Volume and Issue: unknown, P. 100911 - 100911
Published: March 1, 2025
Language: Английский
Citations
0
Nanomaterials, Journal Year: 2025, Volume and Issue: 15(7), P. 539 - 539
Published: April 2, 2025
This study investigates the synthesis and characterization of zein nanoparticles (ZNp) loaded with grape pomace extract (GPE) from Vitis vinifera L. for applications in controlled release antioxidant delivery. Grape pomace, a byproduct winemaking industry, is rich bioactive compounds, including phenols flavonoids, which possess properties. To overcome limitations these such as photosensitivity thermal degradation, they were incorporated into using antisolvent technique. The physicochemical properties ZNp-GPE system thoroughly characterized, size, morphology, ζ-potential, total phenol content. Results showed high encapsulation efficiency (89–97%) favorable loading capacities. Characterization techniques, scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), dynamic light scattering (DLS), confirmed that GPE was successfully nanoparticles, thereby enhancing their process did not significantly alter spherical morphology resulted decrease particle size. Total content analysis effectively retained confirming potential efficient delivery systems antioxidants. approach only provides method protecting bioavailability natural antioxidants but also contributes to valorization agricultural waste, promoting sustainability bio-based industries.
Language: Английский
Citations
0
Trends in Food Science & Technology, Journal Year: 2024, Volume and Issue: unknown, P. 104809 - 104809
Published: Nov. 1, 2024
Language: Английский
Citations
3
Microbial Cell Factories, Journal Year: 2024, Volume and Issue: 23(1)
Published: Dec. 23, 2024
This comprehensive review explores the emergence of titanium dioxide nanoparticles (TiO
Language: Английский
Citations
3
Journal of Cellular and Molecular Medicine, Journal Year: 2024, Volume and Issue: 28(11)
Published: June 1, 2024
Chemotherapy resistance remains a significant challenge in treating ovarian cancer effectively. This study addresses this issue by utilizing dual drug-loaded nanomicelle system comprising albendazole (ABZ) and paclitaxel (PTX), encapsulated novel carrier matrix of D-tocopheryl polyethylene glycol 1000 succinate vitamin E (TPGS), soluplus folic acid. Our objective was to develop optimize nanoparticulate delivery using solvent evaporation techniques enhance the therapeutic efficacy against cancer. The formulation process involved pre-formulation, formulation, optimization, comprehensive characterization micelles. Optimization conducted through 32 factorial design, focusing on effects polymer ratios particle size, zeta potential, polydispersity index (PDI) entrapment efficiency (%EE). optimal demonstrated improved dilution stability, as indicated critical micelle concentration (CMC) 0.0015 mg/mL for TPGS-folic acid conjugate (TPGS-FOL). Extensive included differential scanning calorimetry (DSC), nuclear magnetic resonance (NMR), Fourier-transform infrared spectroscopy (FTIR). release profile exhibited an initial burst followed sustained over 90 h. cytotoxic potential formulated micelles superior that drugs alone, assessed MTT assays SKOV3 cell lines. Additionally, vivo studies confirmed presence both plasma tumour tissues, suggesting effective targeting penetration. In conclusion, developed TPGS-Fol-based nanomicelles co-delivering ABZ PTX show promising results overcoming drug resistance, enhancing solubility, sustaining release, improving outcomes treatment.
Language: Английский
Citations
2