Harnessing sulfur-doped carbon nanodots conjugated with IDO inhibitors act as a dual-mode breast cancer immunotherapy

Journal of Controlled Release, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

Optimizing Polyethylene Glycol Coating for Stealth Nanodiamonds

ACS Applied Materials & Interfaces, Journal Year: 2025, Volume and Issue: unknown

Published: March 24, 2025

Nanodiamonds (NDs) have emerged as potential candidates for versatile platforms in nanomedicine, offering unique properties that enhance their utility drug delivery, imaging, and therapeutic applications. To improve biocompatibility nanomedical applicability, NDs are coated with organic polymer chains, such poly(ethylene glycol) (PEG), which well known to prolong blood-circulating lifetime by reducing the surface adsorption of serum proteins. Theoretical simulations useful tools define, at atomic level, optimal parameters guide presentation coating chains biological environment interaction In this work, we perform atomistic molecular dynamics (MD) several PEGylated spherical ND models immersed a realistic physiological medium. particular, evaluate effect chain's terminal group, length, grafting density, core dimension on both structural PEG nanoconjugates aqueous phase. Moreover, investigate role played chemical nature material through comparative analysis titanium dioxide (TiO2) nanoparticle (NP). Among all evaluated, find chain NP key factors determining dynamic behavior nanosystems solution, whereas group only play marginal role. These can be strategically adjusted identify conditions enhanced clinical performance. Finally, prove prevents aggregation two particles. We believe computational study will provide valuable insights experimental community, supporting rational design polymer-coated inorganic NPs more efficient

Language: Английский

Strategies to overcome the limitations of current organoid technology - engineered organoids

Journal of Tissue Engineering, Journal Year: 2025, Volume and Issue: 16

Published: April 1, 2025

Organoids, as 3D in vitro models derived from stem cells, have unparalleled advantages over traditional cell and animal for studying organogenesis, disease mechanisms, drug screening, personalized diagnosis treatment. Despite the tremendous progress made organoid technology, translational application of organoids still presents enormous challenges due to complex structure function human organs. In this review, limitations technologies are first described. Next, we explore ways address many cultures by engineering various dimensions systems. Finally, discuss future directions field, including potential roles simulated microphysiology system We hope that review inspires research into system.

Language: Английский