Sequence of monomers and position of stereocenters matter for thermal properties of stereocontrolled oligourethanes
ChemPhysChem,
Journal Year:
2024,
Volume and Issue:
25(17)
Published: May 16, 2024
Polyurethanes
are
commodity
materials
used
for
multiple
applications.
In
recent
years,
a
new
category
of
polyurethane
material
has
emerged,
characterized
by
the
lack
polymer
molar
mass
dispersity,
control
monomer
arrangement
in
chain,
and
even
full
stereocontrol.
Various
multistep
synthesis
strategies
have
been
developed
to
fabricate
sequence-defined
polyurethanes.
However,
synthesizing
stereocontrolled
polyurethanes
with
controlled
sequence
is
still
challenge.
structural
precision,
as
represented
biopolymers,
i.
e.
proteins
or
nucleic
acids,
opened
application
directions
these
groups
materials.
It
shown
that
can
be
biomimetics,
information
carriers,
molecular
tags,
strictly
properties.
Precise
macromolecules
allows
us
fine-tune
properties
polymers
specific
needs.
Therefore,
it
essential
collect
on
sequence-structure
relationship
polymers.
our
work,
we
present
synthetic
pathways
make
stereo-defined
oligourethanes.
We
demonstrate
details,
e.,
sequences
position
stereocenter,
tremendous
effect
thermal
model
show
introduction
chirality
constitutional
isomerization
program
characteristics
polymers,
which
key
features
Language: Английский
Sequence-defined structural transitions by calcium-responsive proteins
Marina P. Chang,
No information about this author
Winnie Huang,
No information about this author
Gatha Shambharkar
No information about this author
et al.
Published: Aug. 20, 2024
Biopolymer
sequences
dictate
their
functions,
and
protein-based
polymers
are
a
promising
platform
to
establish
sequence–function
relationships
for
novel
biopolymers.
To
efficiently
explore
vast
sequence
spaces
of
natural
proteins,
repetition
is
common
strategy
tune
amplify
specific
functions.
This
applied
repeats-in-toxin
(RTX)
proteins
with
calcium-responsive
folding
behavior,
which
stems
from
tandem
repeats
the
nonapeptide
GGXGXDXUX
in
X
can
be
any
amino
acid
U
hydrophobic
acid.
determine
functional
range
this
nonapeptide,
we
modified
naturally
occurring
RTX
protein
that
forms
β-roll
structures
presence
calcium.
Sequence
modifications
focused
on
calcium-binding
turns
within
repetitive
region,
including
either
global
substitution
nonconserved
residues
or
complete
replacement
consensus
GGAGXDTLY.
Some
disrupted
typical
transition
intrinsically
disordered
random
coils
folded
β
rolls,
despite
conservation
underlying
sequence.
Proteins
enriched
smaller,
acids
adopted
secondary
absence
calcium
underwent
structural
rearrangement
calcium-rich
environments.
In
contrast,
bulkier,
hydrophilic
maintained
intrinsic
disorder
These
results
indicate
significant
role
folding,
thereby
revealing
leverage
design
tunable,
Language: Английский
Sequence-defined structural transitions by calcium-responsive proteins
Polymer Chemistry,
Journal Year:
2024,
Volume and Issue:
15(47), P. 4864 - 4874
Published: Jan. 1, 2024
Recombinant
protein
engineering
accelerated
the
synthesis
of
sequence-defined,
calcium-responsive
biopolymers.
A
mutation
panel
repeats-in-toxin
(RTX)
proteins
revealed
sequence-dependent
disorder,
calcium
sensitivity,
and
structural
transitions.
Language: Английский
Precision Design of Sequence‐Defined Polyurethanes: Exploring Controlled Folding Through Computational Design
Macromolecular Chemistry and Physics,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 15, 2024
Abstract
This
study
presents
the
exploration
of
sequence‐defined
polyurethanes
(PUs)
as
a
new
class
heteropolymers
capable
precise
conformational
control.
Utilizing
molecular
dynamics
simulations,
folding
behavior
polyurethane
chains
is
investigated
varying
lengths
(11,
20,
and
50
monomers)
in
both
vacuum
aqueous
environments.
The
simulations
reveal
that
heterogeneous
systematically
refold
to
approach
designed
target
structures
better
than
non‐designed
or
with
artificially
disrupted
hydrogen‐bond
networks.
subsequent
synthesis
an
optimized
11‐mer
sequence
(P1)
achieved
through
solid‐phase
chemistry,
thorough
characterization
via
NMR,
MS,
SEC
confirming
accuracy
predicted
its
controlled
chain
length.
Solubility
tests
showed
favorable
results
across
multiple
solvents,
highlighting
versatility
polymer.
research
underscores
potential
emulate
structural
functional
attributes
biological
macromolecules,
opening
pathways
for
their
application
catalysis,
drug
delivery,
advanced
material
design.
findings
illustrate
promising
direction
development
synthetic
polymers
tailored
properties,
emphasizing
transformative
impact
control
polymer
chemistry.
Language: Английский