International Journal of Translational Medicine, Journal Year: 2024, Volume and Issue: 4(4), P. 710 - 725
Published: Dec. 4, 2024
Background: Organ-on-a-chip models have emerged as transformative tools in ophthalmology, offering physiologically relevant platforms for studying ocular diseases and testing therapeutic interventions. These microfluidic devices replicate human eye tissue architecture, addressing limitations of traditional vitro animal models. Methods: A narrative review recent advancements organ-on-a-chip technology was conducted, focusing on simulating structures like the retina cornea their applications such dry disease (DED), age-related macular degeneration (AMD), glaucoma. Results: Advanced successfully mimic key features, providing insights into mechanisms responses. Innovations microengineering cellular integration enhanced these platforms’ translational potential, though challenges scalability regulatory validation persist. Conclusions: are poised to enhance preclinical research clinical ophthalmology. Addressing hurdles will be unlocking full potential drug discovery modeling.
Language: Английский