DNA‐based Precision Tools to Probe and Program Mechanobiology and Organ Engineering DOI Open Access
Nihal Singh, Ayushi Sharma, Anjana Goel

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

DNA nanotechnology represents an innovative discipline that combines with biotechnology. It exploits the distinctive characteristics of deoxyribonucleic acid (DNA) to create nanoscale structures and devices remarkable accuracy functionality. Researchers may complex nanostructures precision specialized functions using DNA's innate stability, adaptability, capacity self-assemble through complementary base-pairing interactions. Integrating multiple disciplines, known as nanobiotechnology, allows production sophisticated nanodevices a broad range applications. These include precise drug delivery systems, extremely sensitive biosensors, construction intricate tissue scaffolds for regenerative medicine. Moreover, combining mechanobiology provides new understanding how small-scale mechanical stresses molecular interactions affect cellular activity development. has potential revolutionize diagnostics, engineering, organ regeneration. This could lead enormous improvements in biomedicine. review emphasizes most recent developments nanotechnology, explicitly highlighting its significant influence on growing involvement engineering. extensive overview present trends, obstacles, future prospects this fast-progressing area.

Language: Английский

Multifunctional DNA-Collagen Biomaterials: Developmental Advances and Biomedical Applications DOI Creative Commons
Nikolaos Pipis, Bryan D. James, Josephine B. Allen

et al.

ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 27, 2025

The complexation of nucleic acids and collagen forms a platform biomaterial greater than the sum its parts. This union biomacromolecules merges extracellular matrix functionality with designable bioactivity acids, enabling advances in regenerative medicine, tissue engineering, gene delivery, targeted therapy. review traces historical foundations critical applications DNA-collagen complexes highlights their capabilities, demonstrating them as biocompatible, bioactive, tunable materials. These form structures across length scales, including nanoparticles, microfibers, hydrogels, process controlled by relative amount each component type acid collagen. broad distribution different types within body contributes to extensive biological relevance complexes. Functional can these complexes, such siRNA, antisense oligonucleotides, DNA origami nanostructures, and, particular, single-stranded aptamers, often distinguished rapid self-assembly at room temperature formation without external stimuli modifications. simple seamless integration collagenous matrices enhances biomimicry bioactivity, provides stability against enzymatic degradation, positioning an advanced system for many angiogenesis, bone regeneration, wound healing, more.

Language: Английский

Citations

2
DNA‐based Precision Tools to Probe and Program Mechanobiology and Organ Engineering DOI Open Access
Nihal Singh, Ayushi Sharma, Anjana Goel

et al.

Small, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

DNA nanotechnology represents an innovative discipline that combines with biotechnology. It exploits the distinctive characteristics of deoxyribonucleic acid (DNA) to create nanoscale structures and devices remarkable accuracy functionality. Researchers may complex nanostructures precision specialized functions using DNA's innate stability, adaptability, capacity self-assemble through complementary base-pairing interactions. Integrating multiple disciplines, known as nanobiotechnology, allows production sophisticated nanodevices a broad range applications. These include precise drug delivery systems, extremely sensitive biosensors, construction intricate tissue scaffolds for regenerative medicine. Moreover, combining mechanobiology provides new understanding how small-scale mechanical stresses molecular interactions affect cellular activity development. has potential revolutionize diagnostics, engineering, organ regeneration. This could lead enormous improvements in biomedicine. review emphasizes most recent developments nanotechnology, explicitly highlighting its significant influence on growing involvement engineering. extensive overview present trends, obstacles, future prospects this fast-progressing area.

Language: Английский

Citations

1