Electrospun Biomimetic Periosteum Promotes Diabetic Bone Defect Regeneration through Regulating Macrophage Polarization and Sequential Drug Release

ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

The inadequate vascularization and abnormal immune microenvironment in the diabetic bone defect region present a significant challenge to osteogenic regulation. Inspired by distinctive characteristics of healing staged defects structure–function relationship natural periosteum, we fabricated an electrospun bilayer biomimetic periosteum (Bilayer@E) promote regeneration defects. Here, inner layer was using coaxial electrospinning fibers, with shell incorporating zinc oxide nanoparticles (ZnO NPs) core containing silicon dioxide (SiO2 mimicking cambium periosteum; outer consisted randomly aligned fibers loaded deferoxamine (DFO), simulating fibrous finally, epigallocatechin-3-gallate (EGCG) coated onto membrane obtain Bilayer@E. presence EGCG on Bilayer@E surface efficiently triggers phenotypic transition macrophages, shifting them from M1 proinflammatory state M2 anti-inflammatory state. Moreover, sequential release ZnO NPs, DFO, SiO2 NPs exhibits antimicrobial while coordinating angiogenesis promoting mineralization cells. Importantly, shows strong vivo tissue periosteal properties rats. integration drug immunomodulation, tailored meet specific requirements during regeneration, offers new insights for advancing application biomaterials this field.

Language: Английский

Bioactive ion engineered 3D printed TCP scaffolds promote vascularized bone regeneration in diabetic bone defects by restoring mitochondrial homeostasis

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 163700 - 163700

Published: May 1, 2025

Language: Английский