Angewandte Chemie International Edition,
Journal Year:
2022,
Volume and Issue:
61(44)
Published: Sept. 9, 2022
Abstract
The
use
of
temperature‐controlled
mechanochemistry
to
enable
the
mechanochemical
nickel‐catalyzed
Suzuki–Miyaura
coupling
is
herein
described.
Transitioning
from
a
capricious
room‐temperature
protocol,
through
heated,
PID‐controlled
programmable
jar
heater
manifold
was
required
deliver
an
efficient
method
for
aryl
sulfamates
(derived
ubiquitous
phenols)
and
boronic
acid
species.
Furthermore,
this
process
conducted
using
base‐metal
nickel
catalyst,
in
absence
bulk
solvent,
air/moisture
sensitive
reaction
set‐ups.
This
methodology
showcased
translation
large‐scale
twin‐screw
extrusion
enabling
200‐fold
scale
increase,
producing
decagram
quantities
C−C
coupled
material.
Angewandte Chemie International Edition,
Journal Year:
2021,
Volume and Issue:
61(9)
Published: Dec. 23, 2021
Abstract
A
one‐pot,
three‐step
protocol
for
the
preparation
of
Grignard
reagents
from
organobromides
in
a
ball
mill
and
their
subsequent
reactions
with
gaseous
carbon
dioxide
(CO
2
)
or
sodium
methyl
carbonate
providing
aryl
alkyl
carboxylic
acids
up
to
82
%
yield
is
reported.
Noteworthy
are
short
reaction
times
significantly
reduced
solvent
amounts
[2.0
equiv.
liquid
assisted
grinding
(LAG)
conditions].
Unexpectedly,
bromides
methoxy
substituents
lead
symmetric
ketones
as
major
products.
Chemical Science,
Journal Year:
2021,
Volume and Issue:
13(2), P. 430 - 438
Published: Dec. 8, 2021
Using
a
high-temperature
ball-milling
technique,
practical
mechanochemical
protocol
for
the
Sonogashira
cross-coupling
of
polyaromatic
halides
was
achieved,
which
provides
efficient
access
to
materials-oriented
aromatic
alkynes.
Advanced Science,
Journal Year:
2022,
Volume and Issue:
9(19)
Published: Jan. 20, 2022
Mechanochemistry
uses
mechanical
force
to
break,
form,
and
manipulate
chemical
bonds
achieve
functional
transformations
syntheses.
Over
the
last
years,
many
innovative
applications
of
mechanochemistry
have
been
developed.
Specifically
for
synthesis
activation
carbon-rich
π-conjugated
materials,
offers
reaction
pathways
that
either
are
inaccessible
with
other
stimuli,
such
as
light
heat,
or
improve
yields,
energy
consumption,
substrate
scope.
Therefore,
this
review
summarizes
recent
advances
in
research
field
combining
viewpoints
polymer
trituration
mechanochemistry.
The
highlighted
mechanochemical
include
materials
optical
probes,
force-induced
release
small
dye
molecules,
polyacetylene,
carbon
allotropes,
materials.
Angewandte Chemie International Edition,
Journal Year:
2022,
Volume and Issue:
61(44)
Published: Sept. 9, 2022
Abstract
The
use
of
temperature‐controlled
mechanochemistry
to
enable
the
mechanochemical
nickel‐catalyzed
Suzuki–Miyaura
coupling
is
herein
described.
Transitioning
from
a
capricious
room‐temperature
protocol,
through
heated,
PID‐controlled
programmable
jar
heater
manifold
was
required
deliver
an
efficient
method
for
aryl
sulfamates
(derived
ubiquitous
phenols)
and
boronic
acid
species.
Furthermore,
this
process
conducted
using
base‐metal
nickel
catalyst,
in
absence
bulk
solvent,
air/moisture
sensitive
reaction
set‐ups.
This
methodology
showcased
translation
large‐scale
twin‐screw
extrusion
enabling
200‐fold
scale
increase,
producing
decagram
quantities
C−C
coupled
material.
