Chemical Society Reviews,
Journal Year:
2021,
Volume and Issue:
50(14), P. 7941 - 8002
Published: Jan. 1, 2021
Electrochemistry
has
recently
gained
increased
attention
as
a
versatile
strategy
for
achieving
challenging
transformations
at
the
forefront
of
synthetic
organic
chemistry.
Electrochemistry's
unique
ability
to
generate
highly
reactive
radical
and
ion
intermediates
in
controlled
fashion
under
mild
conditions
inspired
development
number
new
electrochemical
methodologies
preparation
valuable
chemical
motifs.
Particularly,
recent
developments
electrosynthesis
have
featured
an
use
redox-active
electrocatalysts
further
enhance
control
over
selective
formation
downstream
reactivity
these
intermediates.
Furthermore,
electrocatalytic
mediators
enable
proceed
manner
that
is
mechanistically
distinct
from
purely
methods,
allowing
subversion
kinetic
thermodynamic
obstacles
encountered
conventional
synthesis.
This
review
highlights
key
innovations
within
past
decade
area
electrocatalysis,
with
emphasis
on
mechanisms
catalyst
design
principles
underpinning
advancements.
A
host
oxidative
reductive
are
discussed
grouped
according
classification
transformation
nature
electrocatalyst.
Journal of the American Chemical Society,
Journal Year:
2020,
Volume and Issue:
142(49), P. 20661 - 20670
Published: Nov. 24, 2020
Electrochemistry
grants
direct
access
to
reactive
intermediates
(radicals
and
ions)
in
a
controlled
fashion
toward
selective
organic
transformations.
This
feature
has
been
demonstrated
variety
of
alkene
functionalization
reactions,
most
which
proceed
via
an
anodic
oxidation
pathway.
In
this
report,
we
further
expand
the
scope
electrochemistry
reductive
alkenes.
particular,
strategic
choice
reagents
reaction
conditions
enabled
radical-polar
crossover
pathway
wherein
two
distinct
electrophiles
can
be
added
across
highly
chemo-
regioselective
fashion.
Specifically,
used
strategy
intermolecular
carboformylation,
anti-Markovnikov
hydroalkylation,
carbocarboxylation
alkenes—reactions
with
rare
precedents
literature—by
means
electroreductive
generation
alkyl
radical
carbanion
intermediates.
These
reactions
employ
readily
available
starting
materials
(alkyl
halides,
alkenes,
etc.)
simple,
transition-metal-free
display
broad
substrate
good
tolerance
functional
groups.
A
uniform
protocol
achieve
all
three
transformations
by
simply
altering
medium.
development
provides
new
avenue
for
constructing
Csp3–Csp3
bonds.
Advanced Synthesis & Catalysis,
Journal Year:
2020,
Volume and Issue:
363(1), P. 208 - 214
Published: Nov. 4, 2020
Abstract
The
tandem
cyclization
of
acrylamide
with
diselenides
facilitated
by
electrochemical
oxidation
was
successfully
developed.
This
strategy
provided
an
environmentally
friendly
method
for
the
construction
C−Se
bond.
A
series
seleno
oxindoles
pharmacological
activity
were
obtained
using
this
well‐designed
strategy.
in
vitro
antitumor
compounds
also
screened
through
MTT
assay.
Results
showed
that
exhibited
better
than
other
oxindole
derivatives.
magnified
image
Chemical Society Reviews,
Journal Year:
2022,
Volume and Issue:
51(4), P. 1470 - 1510
Published: Jan. 1, 2022
Recent
developments
in
the
use
of
boron,
silicon,
nitrogen
and
sulfur
derivatives
single-electron
transfer
reactions
for
generation
alkyl
radicals
are
described.
Photoredox
catalyzed,
electrochemistry
promoted
or
thermally-induced
oxidative
reductive
processes
discussed
highlighting
their
synthetic
scope
discussing
mechanistic
pathways.
Advanced Science,
Journal Year:
2022,
Volume and Issue:
10(1)
Published: Nov. 18, 2022
Electro-organic
synthesis
has
attracted
a
lot
of
attention
in
pharmaceutical
science,
medicinal
chemistry,
and
future
industrial
applications
energy
storage
conversion.
To
date,
there
not
been
detailed
review
on
electro-organic
with
the
strategy
heterogeneous
catalysis.
In
this
review,
most
recent
advances
synthesizing
value-added
chemicals
by
catalysis
are
summarized.
An
overview
electrocatalytic
oxidation
reduction
processes
as
well
paired
electrocatalysis
is
provided,
anodic
alcohols
(monohydric
polyhydric),
aldehydes,
amines
discussed.
This
also
provides
in-depth
insight
into
cathodic
carboxylates,
carbon
dioxide,
CC,
C≡C,
reductive
coupling
reactions.
Moreover,
electro-synthesis
methods,
including
parallel
paired,
sequential
divergent
convergent
electrolysis,
Additionally,
strategies
developed
to
achieve
high
electrosynthesis
efficiency
associated
challenges
addressed.
It
believed
that
promising
direction
organic
electrochemistry,
offering
numerous
opportunities
develop
new
reaction
methods.
The Journal of Organic Chemistry,
Journal Year:
2021,
Volume and Issue:
86(13), P. 9055 - 9066
Published: June 23, 2021
A
visible-light-induced
decarboxylation
reaction
was
developed
for
the
synthesis
of
alkylated
benzimidazo[2,1-a]isoquinoline-6(5H)-ones
and
indolo[2,1-a]isoquinolin-6(5H)-ones
under
metal-free
conditions.
Impressively,
metal
catalysts
traditionally
volatile
organic
solvents
could
be
effectively
avoided.
Organic Letters,
Journal Year:
2022,
Volume and Issue:
24(2), P. 642 - 647
Published: Jan. 5, 2022
A
direct
alkoxycarbonylation/cyclization
reaction
is
accomplished
under
visible
light-induced
photoredox
catalysis.
With
this
approach,
a
variety
of
ester-substituted
indolo[2,1-a]isoquinolines
are
prepared
in
good
to
excellent
yields.
It
worth
noting
that
method
not
only
can
afford
the
synthesis
but
also
provide
an
alternative
route
for
generating
complex
target
structures
bearing
carboxylic
esters.
Green Chemistry,
Journal Year:
2022,
Volume and Issue:
24(4), P. 1732 - 1737
Published: Jan. 1, 2022
A
general
visible-light-induced
catalyst-/additive-free
strategy
was
developed
for
the
construction
of
various
aroylated
heterocyclesunder
air
and
room
temperature
conditions.
Advanced Synthesis & Catalysis,
Journal Year:
2022,
Volume and Issue:
364(10), P. 1643 - 1665
Published: April 25, 2022
Abstract
The
chemistry
of
boron
compounds
has
been
profoundly
investigated
in
the
last
decades,
leading
to
ubiquity
many
synthetic
applications
as
well
biologically
active
molecules.
Since
advent
photoredox
catalysis,
an
upsurge
discovery
suitable
radical
precursors
witnessed,
and
is
becoming
a
protagonist
this
field.
Despite
studies
focused
on
trifluoroborates,
use
boronic
acids
esters
have
received
much
less
attention
regard.
Because
their
high
oxidation
potential,
development
methods
enable
involvement
photocatalyzed
reactions
only
recent.
Nonetheless,
review
summarizes
novel
strategies
developed
unlock
role
photochemical
discloses
potential
that
own,
when
intrinsic
chemical
properties
are
exploited.
magnified
image
