Nickel-catalyzed reductive formylation of aryl halides via formyl radical

Chinese Chemical Letters, Journal Year: 2024, Volume and Issue: 35(12), P. 109783 - 109783

Published: March 20, 2024

Language: Английский

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Lewis Basic Salt-Promoted Organosilane Coupling Reactions with Aromatic Electrophiles

Journal of the American Chemical Society, Journal Year: 2021, Volume and Issue: 143(31), P. 11939 - 11945

Published: July 27, 2021

Lewis basic salts promote benzyltrimethylsilane coupling with (hetero)aryl nitriles, sulfones, and chlorides as a new route to 1,1-diarylalkanes. This method combines the substrate modularity selectivity characteristic of cross-coupling practicality base-promoted protocol. In addition, base strategy enables complementary scope existing methods, employs stable easily prepared organosilanes, achieves selective arylation in presence acidic functional groups. The utility this is demonstrated by synthesis pharmaceutical analogues its use multicomponent reactions.

Language: Английский

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Tunable Unsymmetrical Ferrocene Ligands Bearing a Bulky Di-1-adamantylphosphino Motif for Many Kinds of C_sp²–C_sp³ Couplings

ACS Catalysis, Journal Year: 2022, Volume and Issue: 12(9), P. 5123 - 5135

Published: April 15, 2022

A class of ferrocene-based unsymmetrical bidentate ligands containing a di(1-adamantyl)phosphino group, Fc(PAd2)(PR2) (R = Ph, Cy, iPr, tBu) abbreviated as MPhos ligands, and their corresponding (MPhos)PdCl2 pre-catalysts were synthesized in very good yields fully characterized using techniques including single-crystal X-ray crystallography. These utilized for Csp2–Csp3 couplings many kinds name reactions such Murahashi–Feringa, Kumada–Corriu, Negishi, Suzuki–Miyaura with substrate scope isolated yields. About nine "drug-like" molecules also tested successfully to demonstrate potential applications active pharmaceutical ingredient (API) synthesis. The tunability the catalyst system enabled matching sterics electronics ligand that substrates have desirable results over five dozen systems selectivity.

Language: Английский

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Nickel‐Cobalt Bimetallic Strategy Enables Regioselective C8–H Alkylation of Polyaromatics with Inert Alkyl Chlorides

Chinese Journal of Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 11, 2025

Comprehensive Summary A regioselective C8−H alkylation of polyaromatics exampled with inert alkyl chloride is reported. The reaction proceeds via the synergistic participation inexpensive transition metals nickel and cobalt. This approach enables coupling various substituted polyaromatic rings a broad range primary secondary chlorides. Further synthetic applications provide series simple conversions to useful building blocks, suggesting its potency in late‐stage functionalization complex molecules. Mechanistic investigation illustrates that goes through radical process an unusual Ni(II)→Ni(III)→Ni(I) cycle being responsible for rate‐determining C−H insertion radicals, which are generated by homolysis chloroalkane 2‐electrons oxidative addition Co(I).

Language: Английский

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Tri-Molecular Homolytic Combination Mechanism for Carbon–Halogen Bond Activation in Ni/Co Synergistic Catalysis

ACS Catalysis, Journal Year: 2025, Volume and Issue: unknown, P. 4307 - 4316

Published: Feb. 25, 2025

Language: Английский

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