Green Chemistry,
Journal Year:
2022,
Volume and Issue:
24(18), P. 7012 - 7021
Published: Jan. 1, 2022
A
robust
and
convenient
rhodium-catalyzed
unconventionally
regioselective
C–H
activation/[4
+
2]
annulation
for
the
synthesis
of
isoquinolones
which
are
prevalent
in
natural
products
pharmaceuticals
was
developed.
Chemical Communications,
Journal Year:
2023,
Volume and Issue:
59(76), P. 11298 - 11319
Published: Jan. 1, 2023
The
enantioselective
catalytic
cascade
involving
Tsuji-Trost
allylation
has
provided
a
viable
strategy
for
the
construction
of
multiple
asymmetric
C-C
and
C-X
centres
numerous
methods
have
been
developed
around
it
synthesis
various
vital
scaffolds.
synthetic
utility
this
was
enhanced
by
replacing
customary
allyl
acetates
with
ethylene
diacetates/dicarbonates,
vinyl
epoxides,
oxetanes,
carbonates,
cyclopropanes,
enynes,
dienes
using
transition-metal
catalysis.
One
more
milestone
achieved
when
metallaphotocatalysis
necessary
platform
these
cascades
cheaper
metal.
This
review
will
provide
summary
from
2015.
Organic Chemistry Frontiers,
Journal Year:
2021,
Volume and Issue:
8(16), P. 4452 - 4458
Published: Jan. 1, 2021
Efficient
metal-free
[3
+
2]
annulation
of
N-phenoxy
amides
with
gem-difluoroalkenes
has
been
realized
for
the
assembly
2-aminobenzofuran
derivatives
potent
cytotoxicity
against
cancer
cell
lines
and
application
potential
DELs.
Angewandte Chemie,
Journal Year:
2021,
Volume and Issue:
134(1)
Published: Oct. 22, 2021
Abstract
Axially
chiral
open‐chain
olefins
represent
an
underexplored
class
of
platform.
In
this
report,
two
classes
tetrasubstituted
axially
acyclic
have
been
accessed
in
excellent
enantioselectivity
and
regioselectivity
via
C−H
activation
(hetero)arenes
assisted
by
a
migratable
directing
group
en
route
to
coupling
with
sterically
hindered
alkynes.
The
indoles
bearing
N‐aminocarbonyl
afforded
C–N
acrylamides
the
assistance
racemic
zinc
carboxylate
additive.
DFT
studies
suggest
β‐nitrogen
elimination–reinsertion
pathway
for
migration.
Meanwhile,
employment
N‐phenoxycarboxamide
delivered
C−C
enamides
migration
oxidizing
group.
Experiments
that
both
cases
(hetero)arene
substrate
adopts
well‐defined
orientation
during
activation,
which
turn
determines
disposition
alkyne
migratory
insertion.
Synthetic
applications
representative
are
demonstrated.
Organic Letters,
Journal Year:
2021,
Volume and Issue:
23(10), P. 3844 - 3849
Published: April 19, 2021
A
unique
Rh(III)-catalyzed
C–H
activation/[3
+
2]
annulation
of
N-phenoxyacetamides
has
been
developed
for
the
construction
dihydrobenzofurans
via
carbooxygenation
1,3-dienes.
This
transformation
features
a
redox-neutral
process
with
specific
chemoselectivity,
good
substrate/functional
group
compatibility,
and
profound
synthetic
potentials.
preliminary
exploration
to
realize
their
asymmetric
synthesis
have
also
successfully
demonstrated,
which
further
strengthens
practicality
this
approach.
SynOpen,
Journal Year:
2023,
Volume and Issue:
07(04), P. 466 - 485
Published: Sept. 6, 2023
Abstract
Transition-metal-catalyzed
enantioselective
C–H
activation
provides
a
straightforward
strategy
to
synthesize
chiral
molecules
from
readily
available
sources.
In
this
graphical
review,
we
summarize
the
progress
on
half-sandwich
d6-metal
(CoIII,
RhIII,
IrIII,
RuII)-catalyzed
functionalization
reactions.
The
review
is
categorized
according
type
of
metal
catalyst
and
ligand
employed.
Representative
enantio-determining
models
catalytic
cycles
are
presented.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(7), P. 1501 - 1505
Published: Feb. 13, 2024
Asymmetric
C–H
trifluoromethylalkylation
represents
a
novel
and
straightforward
synthetic
method
for
the
construction
of
chiral
CF3-containing
compounds.
However,
reported
examples
remain
limited,
given
challenges
reactivity
enantioselective
control.
Herein,
we
report
SCpRh(III)-catalyzed
asymmetric
aryl
alkenyl
reaction
with
β-trifluoromethyl-α,β-unsaturated
ketones.
The
CF3-bearing
adducts
were
obtained
in
moderate
to
good
yields
high
enantioselectivity
(up
81%
yield
96%
ee).
features
mild
conditions
broad
substrate
scope.
products
could
undergo
diverse
functional
group
transformations.
The Journal of Organic Chemistry,
Journal Year:
2022,
Volume and Issue:
87(9), P. 5713 - 5729
Published: April 12, 2022
Co(III)-catalyzed
regio-
and
chemoselective
redox-neutral
C-H
annulation
of
arylamides/acrylamides
with
1,3-dienes
is
described.
The
present
reaction
was
well
suited
a
less-reactive
1,3-butadiene.
By
employing
this
protocol,
pharmaceutically
important
3,4-dihydroisoquinolinones
were
synthesized
in
good
yields.
Furthermore,
the
prepared
converted
into
highly
oxirane
derivatives
A
plausible
mechanistic
cycle
proposed
supported
by
competition
experiment
kinetic
isotopic
effect
(KIE)
studies.
