SynOpen,
Journal Year:
2023,
Volume and Issue:
07(04), P. 466 - 485
Published: Sept. 6, 2023
Abstract
Transition-metal-catalyzed
enantioselective
C–H
activation
provides
a
straightforward
strategy
to
synthesize
chiral
molecules
from
readily
available
sources.
In
this
graphical
review,
we
summarize
the
progress
on
half-sandwich
d6-metal
(CoIII,
RhIII,
IrIII,
RuII)-catalyzed
functionalization
reactions.
The
review
is
categorized
according
type
of
metal
catalyst
and
ligand
employed.
Representative
enantio-determining
models
catalytic
cycles
are
presented.
Journal of the American Chemical Society,
Journal Year:
2023,
Volume and Issue:
145(46), P. 25293 - 25303
Published: Nov. 8, 2023
Catalytic
carboamination
of
alkenes
is
a
powerful
synthetic
tool
to
access
valuable
amine
scaffolds
from
abundant
and
readily
available
alkenes.
Although
number
approaches
have
been
developed
achieve
the
rapid
buildup
molecular
complexity
in
this
realm,
installation
diverse
carbon
nitrogen
functionalities
onto
unactivated
remains
underdeveloped.
Here
we
present
ligand
design
approach
enable
nickel-catalyzed
three-component
carboamidation
that
applicable
wide
range
alkenyl
derivatives
via
tandem
process
involving
alkyl
migratory
insertion
inner-sphere
metal-nitrenoid
transfer.
With
method,
various
can
be
installed
into
both
internal
terminal
alkenes,
leading
differentially
substituted
diamines
would
otherwise
difficult
access.
Mechanistic
investigations
reveal
tailored
Ni(cod)(BQiPr)
precatalyst
modulates
electronic
properties
presumed
π-alkene-nickel
intermediate
quinone
ligand,
enhanced
carbonickelation
efficiency
across
C═C
bond.
These
findings
establish
nickel's
ability
catalyze
multicomponent
with
high
exquisite
selectivity.
Asian Journal of Organic Chemistry,
Journal Year:
2021,
Volume and Issue:
10(10), P. 2557 - 2561
Published: Sept. 3, 2021
Abstract
A
Rh‐catalyzed
divergent
alkylation
of
indole
derivatives
with
vinyl
carbonate
was
described.
Depending
on
the
substrate
and
solvent,
indoles
reacted
alcohols
to
give
C2
carboxymethylated
adducts
via
a
sequential
three‐component
reaction,
while
indolines
in
toluene
provide
C7
formylmethylated
products.
The
structures
product
3
5
were
further
confirmed
by
X‐ray
analysis.
current
protocol
featured
broad
scope,
tunable
reaction
conditions,
functionalization,
good
regioselectivity.
Chemical Communications,
Journal Year:
2023,
Volume and Issue:
59(47), P. 7216 - 7219
Published: Jan. 1, 2023
A
highly
regio-
and
chemoselective
three-component
assembling
of
N-pyrimidyl
indoles
with
dienes
formaldehyde
in
the
presence
a
Co(III)
catalyst
was
demonstrated.
The
scope
reaction
investigated
variety
indole
derivatives
to
synthesize
substituted
homoallylic
alcohols.
Both
butadiene
isoprene
units
were
compatible
reaction.
To
understand
mechanism,
various
investigations
carried
out,
suggested
plausibility
mechanism
involving
C-H
bond
activation
as
key
step.
SynOpen,
Journal Year:
2023,
Volume and Issue:
07(04), P. 466 - 485
Published: Sept. 6, 2023
Abstract
Transition-metal-catalyzed
enantioselective
C–H
activation
provides
a
straightforward
strategy
to
synthesize
chiral
molecules
from
readily
available
sources.
In
this
graphical
review,
we
summarize
the
progress
on
half-sandwich
d6-metal
(CoIII,
RhIII,
IrIII,
RuII)-catalyzed
functionalization
reactions.
The
review
is
categorized
according
type
of
metal
catalyst
and
ligand
employed.
Representative
enantio-determining
models
catalytic
cycles
are
presented.
