Organic Letters,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 22, 2024
α-Halogenated
geminal
bis(boronates)
are
emerging
as
multifunctional
building
blocks
for
organic
synthesis.
Currently,
their
synthetic
utilization
is
still
restricted
due
to
a
lack
of
efficient
preparation
methods.
Herein,
we
report
direct,
modular
synthesis
gem-iododiborylalkanes
using
alkyl
halides
and
lithiated
chlorodiborylmethane
reagent.
Compared
with
previously
reported
methods,
this
protocol
features
assembly,
high
efficiency,
good
tolerance
various
functional
groups.
Organic Chemistry Frontiers,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 1, 2025
Chiral
sp
3
-geminated
bimetallic
reagents
based
on
B,
Si,
and
Sn
have
drawn
much
attention
due
to
their
unique
structure
reaction
mode.
This
review
summarizes
the
synthesis
of
nonracemic
gem
-borylstannyl,
-borylsilyl,
-diboryl
compounds.
Chinese Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
44(5), P. 1385 - 1385
Published: Jan. 1, 2024
Chiral
1,2-bis(boronic)
esters
are
essential
building
blocks
in
the
field
of
synthetic
chemistry,
and
their
catalytic
asymmetric
synthesis
has
attracted
significant
interest
chemists.Recently,
diboration
olefins,
using
transition
metals
chiral
diols,
emerged
as
straightforward
atom-economical
methods
for
producing
highly
valuable
esters.Asymmetric
hydrogenation
vinyl
bis(boronic)
can
be
a
complementary
approach
to
synthesizing
these
products.Additionally,
borofunctionalization
alkenes
or
alkynes
represents
another
effective
strategy
constructing
scaffolds.A
recent
innovation
involves
migratory
coupling
reactions
with
gem-diborylalkanes,
offering
new
avenues
esters.The
latest
developements
challenges
moleculeshis
summarized,
potential
future
research
directions
this
prospected.
Organic Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 3, 2025
The
carbanion
derived
from
chlorodiborylmethane
can
act
as
a
soft
nucleophile,
while
the
halogen
substituent
subsequently
function
leaving
group.
Taking
advantage
of
this
feature,
we
herein
have
developed
an
efficient
synthesis
gem-diborylcyclopropyl
ketones
diverse
range
enone
substrates.
We
also
demonstrated
synthetic
utility
protocol
by
leveraging
highly
transformable
nature
cyclopropyl
moiety
and
C-B
bonds.
Angewandte Chemie International Edition,
Journal Year:
2022,
Volume and Issue:
61(30)
Published: May 19, 2022
In
this
paper
is
described
an
easily
synthesized
chiral
diazaborolidine
that
inexpensive,
stable,
and
provides
excellent
stereoselection
across
a
number
of
reaction
classes.
These
versatile
compounds
possess
utility
in
four
different
classes
cycloaddition
reactions,
offering
good
yield
stereoselectivity.
X-ray
structure
analysis
insight
about
the
origin
stereocontrol.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 22, 2024
α-Halogenated
geminal
bis(boronates)
are
emerging
as
multifunctional
building
blocks
for
organic
synthesis.
Currently,
their
synthetic
utilization
is
still
restricted
due
to
a
lack
of
efficient
preparation
methods.
Herein,
we
report
direct,
modular
synthesis
gem-iododiborylalkanes
using
alkyl
halides
and
lithiated
chlorodiborylmethane
reagent.
Compared
with
previously
reported
methods,
this
protocol
features
assembly,
high
efficiency,
good
tolerance
various
functional
groups.
