Reactivity of Alkynes with M-C Bonds generated through C-H Activation DOI Creative Commons
Shyam Kumar Banjare, Pranav Shridhar Mahulkar, Tanmayee Nanda

et al.

Published: March 10, 2022

Transition metal-catalyzed C-H activation and functionalization with various coupling partners is a well-explored area of research. Among the used, alkynes occupy prominent position on account their varied reactivity. Due to low steric demand high degree unsaturation they effectively overlap metal d-orbitals form multiple bond-forming events giving rise complex skeletons that are otherwise challenging synthesize. This makes alkyne one most successful in terms number useful transformations. Remarkably, by changing reaction conditions transition-metals from 5d 3d, behaviors also change. Despite enormous explorations alkynes, there still lot more possible ways which can be made react M-C bonds generated through activation. Especially development new valent first-row catalysts, plenty scope for this chemistry evolve as explored areas research coming years. Therefore, review topic both timely synthetic chemists who working area. In review, we have highlighted diverse reactivity transition metals applications along some our thoughts future prospects.

Language: Английский

Iridium catalysed C2 site-selective methylation of indoles using a pivaloyl directing group through weak chelation-assistance DOI Creative Commons

Subban Kathiravan,

Tianshu Zhang, Ian A. Nicholls

et al.

RSC Advances, Journal Year: 2023, Volume and Issue: 13(17), P. 11291 - 11295

Published: Jan. 1, 2023

Here we present an iridium catalysed C2-selective methylation of indoles using methyltrifluoroborate as a source methyl group. The catalyst selectively discriminates the indole C2 and C4 C-H bonds by coordination with pivaloyl directing

Language: Английский

Citations

1
Reactivity of Alkynes with M-C Bonds generated through C-H Activation DOI Creative Commons
Shyam Kumar Banjare, Pranav Shridhar Mahulkar, Tanmayee Nanda

et al.

Published: March 10, 2022

Transition metal-catalyzed C-H activation and functionalization with various coupling partners is a well-explored area of research. Among the used, alkynes occupy prominent position on account their varied reactivity. Due to low steric demand high degree unsaturation they effectively overlap metal d-orbitals form multiple bond-forming events giving rise complex skeletons that are otherwise challenging synthesize. This makes alkyne one most successful in terms number useful transformations. Remarkably, by changing reaction conditions transition-metals from 5d 3d, behaviors also change. Despite enormous explorations alkynes, there still lot more possible ways which can be made react M-C bonds generated through activation. Especially development new valent first-row catalysts, plenty scope for this chemistry evolve as explored areas research coming years. Therefore, review topic both timely synthetic chemists who working area. In review, we have highlighted diverse reactivity transition metals applications along some our thoughts future prospects.

Language: Английский

Citations

0