Russian Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
93(11), P. RCR5140 - RCR5140
Published: Oct. 30, 2024
The
urgency
of
improving
the
efficiency
known
methods
and
developing
new
ones
for
synthesis
unsaturated
silanes
is
caused
by
need
to
obtain
useful
compounds,
including
biologically
active
ones,
on
their
basis.
This
review
considers
preparation
silanes,
transformations
prospects
use
as
precursors
in
organic
organoelement
synthesis.
A
large
number
substituted
organosilicon
products
are
given,
those
capable
further
functionalization
formation
heterocycles,
silaheterocycles.<br>
bibliography
includes
205
references.
Organic Letters,
Journal Year:
2022,
Volume and Issue:
24(28), P. 5090 - 5094
Published: July 13, 2022
We
herein
report
an
unprecedented
pathway
to
access
γ-lactams
using
acetonitrile
analogues
as
coupling
partners
without
oxidants,
ligands,
and
Lewis
acids.
The
reaction
undergoes
Rh-catalyzed
C(sp2)–H
addition
carbon-bound
nitriles
with
the
aid
of
amide
traceless
auxiliary
followed
by
annulation
sequence,
featuring
a
broad
substrate
scope,
good
functional
group
tolerance,
excellent
chemo/stereoselectivity.
Scale-up
reactions
late-stage
derivatizations
highlight
potential
synthetic
utility
this
methodology.
A
plausible
mechanism
is
proposed
based
on
mechanistic
investigations.
Advanced Synthesis & Catalysis,
Journal Year:
2022,
Volume and Issue:
364(24), P. 4421 - 4426
Published: Nov. 14, 2022
Abstract
An
approach
for
2‐acyl
indolines
synthesis
through
Cobalt‐catalyzed
C−H
activation/[3+2]
annulation
of
aniline
derivatives
and
acrylates
is
described.
The
method
employs
cobalt
catalyst
to
afford
a
wide
variety
functionalized
2‐acylindolines
with
high
regioselectivity.
mechanism
investigated
by
KIE
experiments
deuterium‐labeling
experiment.
gram‐scale
synthetic
transformations
are
also
conducted,
confirming
the
scalability
application
value.
magnified
image
Organic Chemistry Frontiers,
Journal Year:
2023,
Volume and Issue:
10(9), P. 2128 - 2137
Published: Jan. 1, 2023
Divergent
oxidative
Heck
reaction
has
proven
to
be
reliable
for
the
rapid
construction
of
molecular
complexity,
while
olefins
switched
outcome
that
remained
underexplored.
The Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
88(11), P. 7320 - 7327
Published: May 11, 2023
The
rhodium(III)-catalyzed
reaction
of
aniline
derivatives
that
contain
a
pyrimidine-directing
group
with
vinylsilanes
results
in
the
formation
C3-substituted
indoline
derivatives.
path
and
product
density
functional
theory
calculations
were
analyzed.
This
study
reveals
whole
catalysis
can
be
characterized
following
stages:
(I)
C-H
activation
via
concerted
metalation
deprotonation,
(II)
2,1-vinylsilane
insertion,
(III)
deprotonation
NH
amide
proton,
(IV)
oxidation
Ag+,
(V)
reductive
elimination.
These
steps
are
kinetically
thermodynamically
feasible
for
experimental
realization
under
mild
conditions,
insertion
step
barrier
22.0
kcal/mol
should
not
only
critical
regioselectivity
but
also
rate-determining
during
catalysis.
Computations
reveal
Ag+
accelerate
elimination
after
natural
intermediate,
thus
highlighting
role
as
catalytic
promoter
oxidatively
induced
reactivity
Rh
catalyst
synthesis.
Russian Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
93(11), P. RCR5140 - RCR5140
Published: Oct. 30, 2024
The
urgency
of
improving
the
efficiency
known
methods
and
developing
new
ones
for
synthesis
unsaturated
silanes
is
caused
by
need
to
obtain
useful
compounds,
including
biologically
active
ones,
on
their
basis.
This
review
considers
preparation
silanes,
transformations
prospects
use
as
precursors
in
organic
organoelement
synthesis.
A
large
number
substituted
organosilicon
products
are
given,
those
capable
further
functionalization
formation
heterocycles,
silaheterocycles.<br>
bibliography
includes
205
references.
