The Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 20, 2025
Aerobic
oxidative
cross-dehydrogenative
couplings
of
1,2,3,4-tetrahydroisoquinolines
were
developed
using
a
Mn(acac)3
and
ethyl
2-(4-nitrophenyl)hydrazine-1-carboxylate
cocatalytic
system.
Nucleophiles,
including
nitroalkanes,
dialkyl
malonates,
acetophenones,
indoles,
phosphonates,
phosphine
oxides,
successfully
employed
to
produce
α-functionalized
1,2,3,4-tetrahydroisoquinolines.
Control
experiments
revealed
that
radical
species
are
not
involved
in
the
mechanism.
Additionally,
1H
NMR
HRMS
analyses
stoichiometric
reaction
identified
an
aminal
structure
as
crucial
intermediate.
Computational
studies
further
support
plausibility
hydride
transfer
process
oxidation
instead
triazane
pathway,
which
was
predominantly
proposed
DEAD-mediated
reaction.
Angewandte Chemie International Edition,
Journal Year:
2023,
Volume and Issue:
62(23)
Published: March 25, 2023
Rational
design
of
polymer
structures
at
the
molecular
level
promotes
iteration
high-performance
photocatalyst
for
sustainable
photocatalytic
hydrogen
peroxide
(H2
O2
)
production
from
oxygen
and
water,
which
also
lays
basis
revealing
reaction
mechanism.
Here
we
report
a
benzoxazine-based
m-aminophenol-formaldehyde
resin
(APFac)
polymerized
ambient
conditions,
exhibiting
superior
H2
yield
long-term
stability
to
most
polymeric
photocatalysts.
Benzoxazine
structure
was
identified
as
crucial
active
segment
in
APFac.
Favorable
adsorption
oxygen/intermediates
on
benzoxazine
commendable
product
selectivity
accelerated
kinetically
stepwise
single-electron
reduction
reaction.
The
proposed
phenolic
provides
possibility
batches
industrial
application,
sheds
light
de
novo
analysis
metal-free
Advanced Functional Materials,
Journal Year:
2024,
Volume and Issue:
34(52)
Published: Aug. 27, 2024
Abstract
Herein,
a
rational
strategy
is
presented
to
reduce
the
energy
barrier
of
singlet
ground
state
excited
transitions,
whilst
simultaneously
reducing
losses
in
populating
triplet
states.
The
approach
relies
on
constructing
3D
space
connected
donor–acceptor
systems
COFs.
D–A
system
8‐connected
COFs
(denoted
as
COF‐1
and
COF‐2)
allows
efficient
transfer
electrons,
overcoming
traditional
electron
transport
limitations
2D
significantly
boosting
solar
utilization
efficiency
under
visible
light
irradiation.
COF‐2,
possessing
an
extended
π‐conjugated
structure
relative
COF‐1,
demonstrated
high
selectivity
for
photocatalytic
generation
H
2
O
(6.93
mmol
g
−1
h
)
natural
seawater
without
need
sacrificial
reagents,
exceeding
performance
most
previously
reported
COF‐based
photocatalysts.
this
work
offers
new
optimizing
photocatalysts
production
other
applications.
Chemical Communications,
Journal Year:
2022,
Volume and Issue:
58(55), P. 7593 - 7607
Published: Jan. 1, 2022
Thermal,
photochemical,
or
electrochemical-mediated
decarboxylation
of
oxamic
acids
generate
nucleophilic
carbamoyl
radicals,
which
react
efficiently
with
unsaturated
systems,
but
also
amines,
alcohols
and
thiols
under
oxidative
conditions.
Chemical Reviews,
Journal Year:
2024,
Volume and Issue:
124(12), P. 7907 - 7975
Published: May 29, 2024
The
increasing
importance
of
azaheterocyclic
phosphonates
in
the
agrochemical,
synthetic,
and
medicinal
field
has
provoked
an
intense
search
development
synthetic
routes
for
obtaining
novel
members
this
family
compounds.
This
updated
review
covers
methodologies
established
since
2004,
focusing
on
synthesis
phosphonates,
which
phosphonate
moiety
is
directly
substituted
onto
to
structure.
Emphasizing
recent
advances,
classifies
newly
developed
approaches
according
ring
size
providing
information
biological
activities
whenever
available.
Furthermore,
summarizes
various
methods
formation
C–P
bonds,
examining
sustainable
such
as
Michaelis–Arbuzov
reaction,
Michaelis–Becker
Pudovik
Hirao
coupling,
Kabachnik–Fields
reaction.
After
analyzing
applications
investigated
years,
a
predominant
focus
evaluation
these
compounds
anticancer
agents
evident.
emerging
underline
versatility
potential
compounds,
highlighting
need
continued
research
expand
interesting
family.
Organic Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 23, 2025
Herein,
a
N-phenylphenothiazine-based
hyper-cross-linked
polymer
(PTH-HCP)
was
finely
designed
and
constructed,
which
serves
as
metal-free
heterogeneous
photocatalyst
for
organic
transformations.
Characterization
experiments
have
shown
that
this
demonstrates
outstanding
stability,
extensive
surface
area,
exceptional
photoelectric
response
properties.
Moreover,
PTH-HCP
showed
good
catalytic
efficiency
recyclability
in
the
photochemically
driven
difluoromethylation/cyclization
reactions.
This
work
provides
strategy
design
construction
of
photocatalysts
offers
support
their
broad
prospects
synthetic
applications.
The Journal of Organic Chemistry,
Journal Year:
2022,
Volume and Issue:
87(15), P. 10146 - 10157
Published: July 13, 2022
A
mild
and
facile
photo-induced
cascade
radical
addition/cyclization
of
unactivated
alkenes
has
been
reported,
through
which
a
variety
biologically
valuable
phosphine-containing
quinazolinones
could
be
obtained
in
moderate
to
good
yields.
The
protocol
was
characterized
by
conditions,
broad
substrate
scope,
high
atomic
economy.
