Angewandte Chemie,
Journal Year:
2022,
Volume and Issue:
134(39)
Published: Aug. 3, 2022
Abstract
New
technology
is
reported
that
enables
Negishi
couplings
to
be
run
under
sustainable,
far
greener
conditions.
Thus,
ppm
Pd‐containing
nanoparticles
(NPs)
have
been
developed
catalyze
in
recyclable
water
very
mild
These
heterogeneous
reactions
involve
loadings
of
Pd
typically
only
2500
(0.25
mol
%).
Highly
functionalized
aromatic
and
heteroaromatic
bromides
readily
participate,
including
examples
taken
from
the
Merck
Informer
Library
indicative
functional
group
tolerance
associated
with
these
couplings.
Direct
comparisons
existing
literature
routes
are
made.
Very
low
residual
levels
newly
formed
products
expected,
as
determined
by
ICP‐MS.
The
reagent
involved
has
extensively
characterized
via
DLS,
TEM,
cryo‐TEM,
EDX
measurements.
European Journal of Inorganic Chemistry,
Journal Year:
2023,
Volume and Issue:
26(12)
Published: Feb. 16, 2023
Abstract
Unsymmetrical
gold(III)‐dithiolene
complexes
are
potential
candidates
for
molecular
materials
that
exhibit
thermal
structural
phase
transitions.
In
this
study,
unsymmetrical
ppy‐gold(III)
(ppy
−
=
C
‐deprotonated‐2‐phenylpyridine(−))
[AuC5]
and
[AuC6]
coordinated
by
dithiolene
ligands
containing
tetrathiafulvalene
(TTF)
skeletons
with
pentylthio
(2‐{bis(pentylthio)‐1,3‐dithiol‐2‐ylidene}‐1,3‐dithiol‐4,5‐dithiolate(2−))
hexylthio
groups
(2‐{bis(hexylthio)‐1,3‐dithiol‐2‐ylidene}‐1,3‐dithiol‐4,5‐dithiolate(2−))
were
synthesized.
Both
exhibited
a
large
absorption
band
at
approximately
508
nm,
owing
to
intramolecular
ligand‐to‐ligand
charge
transfer.
One‐dimensional
columnar
structures
head‐to‐tail
arrangements
around
the
metal
ions
constructed
in
crystals.
The
flexible
alkylthio
intercalated
into
crystalline
spaces
between
columns.
exhibits
simple
transition
198
°C
isotropic
phases
irreversibly.
of
observed
25
melted
148
°C.
Another
grew
above
very
slow
crystallization
rate
from
liquid
was
completely
transformed
an
200
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
unknown
Published: July 22, 2024
Abstract
Aryl
fluorosulfates
of
varying
complexities
have
been
used
in
amination
reactions
water
using
a
new
Pd
oxidative
addition
complex
(
OAC‐1
)
developed
specifically
to
match
the
needs
fine
chemicals
industry,
not
only
terms
functional
group
tolerance,
but
also
reflecting
time
considerations
associated
with
these
important
C−N
couplings.
Also
especially
noteworthy
is
that
they
replace
both
PFAS‐related
triflates
and
nonaflates,
which
are
today
out
favor
due
recent
government
regulations.
The
based
on
BippyPhos
ligand
at
low
loadings
under
aqueous
micellar
conditions.
Moreover,
it
easily
prepared
stable
long
term
storage.
DFT
calculations
OAC
precatalyst
compare
well
X‐ray
structure
crystals
π‐complexation
aromatic
system
confirm
NMR
data
showing
mixture
conformers
solution
differ
from
rotation
phenyl
t
‐butyl
substituents.
An
extensive
variety
coupling
partners,
including
pharmaceutically
relevant
APIs,
readily
participate
mild
environmentally
responsible
reaction
Angewandte Chemie,
Journal Year:
2024,
Volume and Issue:
136(43)
Published: July 22, 2024
Abstract
Aryl
fluorosulfates
of
varying
complexities
have
been
used
in
amination
reactions
water
using
a
new
Pd
oxidative
addition
complex
(
OAC‐1
)
developed
specifically
to
match
the
needs
fine
chemicals
industry,
not
only
terms
functional
group
tolerance,
but
also
reflecting
time
considerations
associated
with
these
important
C−N
couplings.
Also
especially
noteworthy
is
that
they
replace
both
PFAS‐related
triflates
and
nonaflates,
which
are
today
out
favor
due
recent
government
regulations.
The
based
on
BippyPhos
ligand
at
low
loadings
under
aqueous
micellar
conditions.
Moreover,
it
easily
prepared
stable
long
term
storage.
DFT
calculations
OAC
precatalyst
compare
well
X‐ray
structure
crystals
π‐complexation
aromatic
system
confirm
NMR
data
showing
mixture
conformers
solution
differ
from
rotation
phenyl
t
‐butyl
substituents.
An
extensive
variety
coupling
partners,
including
pharmaceutically
relevant
APIs,
readily
participate
mild
environmentally
responsible
reaction
Organic Letters,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 9, 2024
Novel
monophosphine
ligands
L1
and
L2
with
a
C–P
ring
were
designed
synthesized
for
the
efficient
Pd-catalyzed
C(sp2)–C(sp3)
Suzuki
coupling.
With
0.5
mol
%
Pd2dba3
2
L1,
aryl
halides
coupled
alkylboronic
acids
to
give
products
in
up
99%
yield.
The
thianthrene
salt
was
further
applied
late-stage
methylation
97%
active
pharmaceutical
ingredient
lumacaftor
by
aryl–alkyl
aryl–aryl
coupling
reactions
using
L2.
