Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(21), P. 4514 - 4519
Published: May 17, 2024
An
efficient
protocol
of
enantioselective
thiolative
azidation
sulfone-tethered
alkenes
via
a
chiral
chalcogenide
catalyzed
electrophilic
reaction
is
disclosed.
A
series
enantioenriched
sulfones
bearing
remote
stereogenic
centers
was
achieved
with
good
yields
and
high
enantioselectivities
linear
unsaturated
cyclic
sulfones.
Mechanistic
studies
revealed
the
importance
sulfone
group
in
improvement
reactivity
enantioselectivity
reaction.
Organic Chemistry Frontiers,
Journal Year:
2022,
Volume and Issue:
10(1), P. 92 - 98
Published: Nov. 11, 2022
Synthesis
of
sulfonyl-containing
axially
chiral
styrenes
through
a
catalytic
asymmetric
reaction
4-substituted
Hantzsch
esters,
sodium
hydrogen
sulfite
and
1-(arylethynyl)naphthalen-2-ols
is
reported.
The Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
88(13), P. 9293 - 9305
Published: June 7, 2023
A
visible-light-induced
three-component
reaction
of
2-aryl
indoles/benzimidazoles,
Hantzsch
esters,
and
sodium
pyrosulfite
through
a
radical
cascade
cyclization
process
with
the
insertion
sulfur
dioxide
is
described.
It
provides
novel
powerful
way
for
synthesis
alkylsulfonated
isoquinolinones.
esters
Na2S2O5
are
employed
as
alkyl
precursors
SO2
surrogate,
respectively.
This
transformation
exhibits
good
functional
group
tolerance
substrate
applicability
under
mild
conditions.
Organic Chemistry Frontiers,
Journal Year:
2023,
Volume and Issue:
10(14), P. 3567 - 3576
Published: Jan. 1, 2023
A
palladium
catalyzed
multi-component
cross-electrophile
coupling
involving
sulfur
dioxide
is
presented
here.
This
protocol
features
mild
reaction
conditions,
wide
substrate
scope,
good
functional
group
tolerance
and
excellent
regioselectivity.
Organic & Biomolecular Chemistry,
Journal Year:
2024,
Volume and Issue:
22(29), P. 5868 - 5885
Published: Jan. 1, 2024
The
importance
of
sulfonyl-group-containing
compounds,
such
as
sulfonamides,
sulfones,
sulfinate
esters,
and
sulfonyl
fluorides,
in
pharmaceuticals,
bioactive
molecules,
natural
products
cannot
be
overstated.
new
development
palladium-catalyzed
sulfonylation
Nature Communications,
Journal Year:
2025,
Volume and Issue:
16(1)
Published: Jan. 2, 2025
Unsymmetric
disulfides
are
prevalent
in
natural
products
and
essential
medicinal
chemistry
materials
science,
but
their
robust
synthesis
poses
significant
challenges.
In
this
paper,
we
report
an
expeditous
transition-metal-free
methodology
for
synthesizing
unsymmetric
through
the
addition
of
perthiyl
radicals
to
alkenes.
This
study
marks
use
generating
by
reacting
SO2
with
unactivated
alkyl
(pseudo)halides
(Cl/Br/I/OTs).
Various
primary,
secondary
tertiary
substituted
different
functional
groups
successfully
function
as
suitable
reactants.
The
formation
involvement
reaction
process
verified
mechanistic
studies
DFT
calculations.
Overall,
method
leverages
readily
available
electrophiles
alkenes
alongside
a
single
setup
efficiently
form
both
carbon-sulfur
sulfur-sulfur
bonds
simultaneously.
Here,
authors
novel
transition-metalfree
This
review
summarizes
recent
progress
in
EDA
complex-promoted
C–S
bond
formation
using
various
sulfur-containing
substrates
under
mild
conditions
via
visible
light
irradiation.
New Journal of Chemistry,
Journal Year:
2024,
Volume and Issue:
48(12), P. 5101 - 5106
Published: Jan. 1, 2024
A
reductive
cross-coupling
strategy
for
the
synthesis
of
sulfone-containing
oxindoles
was
presented.
Moreover,
using
amines
instead
alkyl
bromides,
a
palladium-catalyzed
domino
cyclization/aminosulfonylation
also
established.
Organic Chemistry Frontiers,
Journal Year:
2024,
Volume and Issue:
11(15), P. 4275 - 4283
Published: Jan. 1, 2024
A
copper-catalyzed
enantioselective
four-component
reaction
via
the
insertion
of
sulfur
dioxide
toward
synthesis
chiral
sulfones
bearing
an
all-carbon
quaternary
stereocenter
at
β
position
is
reported.
