Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(43), P. 9257 - 9262
Published: Oct. 18, 2024
A
transition-metal-
and
harsh-oxidant-free
strategy
for
diastereoselective
homocoupling
of
benzylic
α-boryl
carbanions
has
been
developed.
Central
to
this
methodology
is
the
ability
halogen
transfer
reagent
seamlessly
integrate
halogenation
substitution
within
a
compatible
process.
Additionally,
also
applicable
diarylmethanes
alkylheteroarenes.
Substrates
bearing
oxidatively
sensitive
functional
groups
were
well-tolerated.
Preliminary
studies
suggest
that
hydrogen
bond
between
two
boryl
contributes
high
diastereoselectivities.
Advanced Synthesis & Catalysis,
Journal Year:
2023,
Volume and Issue:
365(24), P. 4603 - 4608
Published: Nov. 1, 2023
Abstract
Herein,
a
photocatalytic
system
for
defluorinative
[4+2]
annulation
of
gem
‐difluoroalkenes
with
unactivated
alkenes
is
realized.
This
protocol
was
compatible
broad
scope
alkenes,
affording
the
diverse
monofluorocyclohexene
products
in
30–95%
yields.
Furthermore,
value
this
method
demonstrated
by
gram‐scale
synthesis,
late‐stage
functionalization
and
synthesis
various
valuable
complex
derivatives.
European Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
27(14)
Published: March 6, 2024
Abstract
Photocatalysis
utilizes
light
as
the
initial
driving
force
for
chemical
reactions,
enabling
reactions
with
high
energy
barriers
in
traditionally
thermal
chemistry
to
proceed
under
mild
conditions.
1,3‐Dicarbonyl
compounds
occur
important
active
molecules
nature
and
are
intermediates
pharmaceutical
syntheses.
In
recent
years,
there
have
been
numerous
studies
of
these
compounds,
it
is
common
practice
pre‐modify
them
before
reaction,
which
is,
however,
unfavorable
atom
economy
process.
This
paper
provides
a
comprehensive
review
latest
advancements
site‐specific
activation
unmodified
1,3‐dicarbonyl
by
photoinduction.
The
focus
on
elucidating
mechanisms
provide
insights
directions
future
research
designing
novel
reactions.
Angewandte Chemie,
Journal Year:
2024,
Volume and Issue:
unknown
Published: May 22, 2024
Abstract
Drawing
inspiration
from
nature
has
long
been
a
cornerstone
of
chemical
innovation,
with
natural
systems
offering
wealth
untapped
potential
for
discovery.
In
this
minireview,
we
delve
into
the
burgeoning
field
cobaloxime
catalysis
in
organic
synthesis,
which
mimics
catalytic
activity
organometallic
alkylcobalamine
enzymes.
Our
focus
lies
on
elucidating
latest
advancements
area,
as
well
delineating
primary
mechanistic
pathways
at
play.
By
describing,
and
comparing
these
mechanisms,
provide
comprehensive
overview
current
state‐of‐the‐art,
while
also
shedding
light
key
unresolved
challenges
that
await
further
exploration.
Chemical Communications,
Journal Year:
2024,
Volume and Issue:
60(78), P. 10958 - 10961
Published: Jan. 1, 2024
A
palladium-catalyzed
coupling
reaction
has
been
developed
for
the
generation
of
tertiary
alkylation
products
by
reacting
olefins
with
diversely
functionalized
1,3-dicarbonyls.
The
involves
C-H
1,3-dicarbonyls
to
produce
a
alcohol,
followed
C-C
bond
cleavage.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(43), P. 9257 - 9262
Published: Oct. 18, 2024
A
transition-metal-
and
harsh-oxidant-free
strategy
for
diastereoselective
homocoupling
of
benzylic
α-boryl
carbanions
has
been
developed.
Central
to
this
methodology
is
the
ability
halogen
transfer
reagent
seamlessly
integrate
halogenation
substitution
within
a
compatible
process.
Additionally,
also
applicable
diarylmethanes
alkylheteroarenes.
Substrates
bearing
oxidatively
sensitive
functional
groups
were
well-tolerated.
Preliminary
studies
suggest
that
hydrogen
bond
between
two
boryl
contributes
high
diastereoselectivities.
