Theoretical Insights into the Mechanism and Origin of Solvent-Dependent Selectivity in the Cyclization of Propargyl Alcohols for the Divergent Synthesis of N-Heterocycles DOI
Xiuyuan Zou, Qing Sun,

Pan Hong

et al.

The Journal of Physical Chemistry A, Journal Year: 2024, Volume and Issue: 128(32), P. 6729 - 6738

Published: Aug. 7, 2024

This study elucidates the mechanisms and principles governing chemoselectivity in synthesizing two distinct N-heterocycles, benzimidazole thiazine benzothiazole imidazole, through BF

Language: Английский

Rh(iii)-catalyzed regioselective versatile indole derivatization: delivering potential of rare β-(1H-indol-2-yl)-β-amino acids in one pot DOI
Shuaizhong Zhang, Jinquan Zhang, Hongbin Zou

et al.

Chemical Communications, Journal Year: 2023, Volume and Issue: 59(33), P. 4978 - 4981

Published: Jan. 1, 2023

Rh-catalyzed selective C-H functionalization of indoles with two routes was developed: an alkenylation-annulation the addition KHSO4 and alkenylation-elimination in presence CsOAc to corresponding products, respectively. Notably, one-pot hydrolysis benzoylation annulation products successfully afforded easily separable β-(1H-indol-2-yl)-β-amino acid derivatives.

Language: Английский

Citations

2
Chemodivergent Parallel Kinetic Resolution of Paracyclophanes: Enantiomer Fishing with Different Substrates DOI Open Access
Qian Liu,

Kunpeng Teng,

Yi Zhang

et al.

Angewandte Chemie, Journal Year: 2024, Volume and Issue: 136(46)

Published: July 25, 2024

Abstract An unprecedented chemodivergent strategy for parallel kinetic resolution (PKR) is disclosed through which two planar chiral products bearing different structures were simultaneously afforded with opposite stereoselectivities. Two achiral esters are activated by one single N‐heterocyclic carbene (NHC) catalyst to react the enantiomers of racemic imine substrate in a fashion. distinct and stereoselectivities respectively from same reaction system good excellent yields, enantio‐ diastereoselectivities. Control experiments studies carried out probe dynamic properties during progress. The pyridine lactam show interesting applications both asymmetric synthesis pesticide development.

Language: Английский

Citations

0
Palladium-Catalyzed Regioselective Carbonylation of 2-Amino-2,3-Diphenylpropanoate to 5/6 Membered Benzolactams DOI
Huaanzi Hu, Can Zhang,

Zhehao Ma

et al.

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Unprecedented free amine-oriented regioselective activations/carbonylations mediated by hexacarbonylmolybdenum have been developed to synthesize 5/6-membered benzolactams respectively.

Language: Английский

Citations

0
Theoretical Insights into the Mechanism and Origin of Solvent-Dependent Selectivity in the Cyclization of Propargyl Alcohols for the Divergent Synthesis of N-Heterocycles DOI
Xiuyuan Zou, Qing Sun,

Pan Hong

et al.

The Journal of Physical Chemistry A, Journal Year: 2024, Volume and Issue: 128(32), P. 6729 - 6738

Published: Aug. 7, 2024

This study elucidates the mechanisms and principles governing chemoselectivity in synthesizing two distinct N-heterocycles, benzimidazole thiazine benzothiazole imidazole, through BF

Language: Английский

Citations

0