Organic Chemistry Frontiers,
Journal Year:
2024,
Volume and Issue:
11(14), P. 3929 - 3938
Published: Jan. 1, 2024
The
dual
activation
of
NHC-catalyst
is
revealed
by
DFT.
Reaction
kinetic
control
the
determining
factor
for
chemoselectivity.
Non-covalent
interactions
among
substrates
and
effect
determine
stereoselectivity.
Abstract
A
new
N,N'-disubstitute
benzimidazolium
ligand
and
its
Ag(I)-NHC
complex
have
been
synthesized",
along
with
symmetric
N,N'-disubstitute
derivative
of
N-Heterocyclic
carbene
ligands.
It
was
possible
to
make
alkyl
bromides
or
both
by
N-alkylating
5,6-methyl-1H-benzo[d]imidazole
fluor
non-fluor
benzyl
halides.
In
situ
deprotonation
compounds
Ag2O
a
catalyzed
reaction
KPF6
were
used
speed
up
the
synthesis
complex.
The
structural
properties
all
molecules
elucidated
NMR
spectroscopy,
PXRD,
FTIR,
elemental
ICP
analysis.
structure
complexes
identified
analyzing
powder
PXRD
diffraction
pattern.
According
analysis,
PF6−
anion
two
NHC
ligands
are
coordinated
an
Ag+
ion
in
linear
geometry
each
fluorinated
antimicrobial
activities
against
Gram-positive,
Gram-negative
bacteria
fungi
showed
that
minimum
inhibitory
concentration
value
is
0.25
µg/mL.
Ag
+
ions
bound
ionic
increased
effects
these
compounds.
