The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 11, 2024
A highly efficient iodide ion (I
Language: Английский
The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 11, 2024
A highly efficient iodide ion (I
Language: Английский
Organic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 11(11), P. 3066 - 3071
Published: Jan. 1, 2024
Iodine-catalyzed 1,2-thio (seleno)amination of alkenes via direct N- and C-centered radical cross-coupling was established to elicit highly regioselective β-triazolized thioalkyl compounds.
Language: Английский
Citations
5Cell Reports Physical Science, Journal Year: 2024, Volume and Issue: 5(8), P. 102139 - 102139
Published: Aug. 1, 2024
Highlights•A light-induced one-pot coupling of PROTAC-like molecules•Cyclic ethers used as linker precursors without any pre-assembly procedure•Reactions complete within 4 h up to 95% yield with a high regioselectivity•A wide substrate scope gave triazole-based linkers structural diversitySummaryProteolysis-targeting chimeras (PROTACs) are powerful approach for targeted protein degradation. One the current bottlenecks developing PROTACs is lack an operationally simple linkerology rapidly construct various linkers. The classic convergent synthesis strategy by pre-assembled two ligands stepwise commonly needs at least four steps give final target PROTACs, which results in low total yields long reaction times (several days) and tedious operations. Here, we develop efficient photocatalytic rapid analogs containing linker-pre-assembled procedure. was completed room temperature. Easily accessible cyclic directly furnish fashion, including alkenyl, polyethylene glycol (PEG), ketone, cyclohexane chains. study provides highly efficient, step-economic, simple, environmentally friendly PROTAC drug discovery.Graphical abstract
Language: Английский
Citations
5European Journal of Medicinal Chemistry, Journal Year: 2024, Volume and Issue: 266, P. 116082 - 116082
Published: Jan. 3, 2024
Language: Английский
Citations
3Organic Letters, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 9, 2025
Herein, a one-pot domino catalyzed three-component process is described, which initiated by palladium/zinc cooperatively cycloaddition between trimethylenemethane (TMM) and unactivated alkyl/aryl imines, followed isomerization Zn(OTf)2-catalyzed DDQ oxidation, furnishing valuable substituted pyrroles. We disclose that the cooperative catalysis affords dual-Zn(OTf)2-stabilized azapalladacycle, wherein Pd–N bond polarized Zn(OTf)2, facilitating unique outer-sphere allylic amination. Moreover, subsequent dehydrogenation can be feasibly promoted zinc catalysis.
Language: Английский
Citations
0The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: March 17, 2025
A photocatalytic diazo triplet carbene-promoted C(sp3)–H oxidative coupling of isochromans and triazoles was developed in up to 83% yield at room temperature air. The radical-like carbenes were used as efficient HAT acceptors, the possible synergistic enabled unprecedented process with a high regioselectivity.
Language: Английский
Citations
0Chemistry Letters, Journal Year: 2023, Volume and Issue: 52(9), P. 703 - 714
Published: July 31, 2023
Abstract Novel synthetic methods for P-chirogenic four-coordinate pentadentate organophosphorus compounds are described. The pathways commenced with the use of phosphates bearing a binaphthyl group and their congeners. These underwent reactions fluoride ion, metal hydroxides, alkoxides, Grignard reagents, resulting in transfer axial chirality from to central phosphorus atom. As result, products incorporating were obtained. substitution these newly formed alkoxides reagents led formation phosphates, phosphonates, phosphinates, some sulfur isologues.
Language: Английский
Citations
8New Journal of Chemistry, Journal Year: 2024, Volume and Issue: 48(17), P. 7754 - 7760
Published: Jan. 1, 2024
A rhodium( ii )-catalyzed reaction of 3-hydroxyisoindolinones and diazos via an intermolecular OH transfer to deliver isoindolinone derivatives containing continuous quaternary carbons as products is developed in high yields up 89%.
Language: Английский
Citations
1ACS Pharmacology & Translational Science, Journal Year: 2024, Volume and Issue: 7(10), P. 3170 - 3191
Published: Oct. 2, 2024
Although the coronavirus disease 2019 (COVID-19) crisis has passed, there remains a necessity for continuous efforts toward developing more targeted drugs and preparing potential future virus attacks. Currently, most of received authorization treatment COVID-19 have exhibited several limitations, such as poor metabolic stability, formidable preparation, uncertain effectiveness. It is still significant to develop novel, structurally diverse small-molecule antiviral targeting SARS-CoV-2 3-chymotrypsin-like protease (3CL
Language: Английский
Citations
1The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 11, 2024
A highly efficient iodide ion (I
Language: Английский
Citations
1