Organic Letters,
Journal Year:
2023,
Volume and Issue:
25(48), P. 8655 - 8660
Published: Nov. 29, 2023
A
novel
protocol
has
been
developed
for
the
Cu-catalyzed
synthesis
of
primary
arylamines
with
meta-substituents
using
cyclohexenone
oxime
esters.
Mechanistic
insights
suggest
that
reaction
proceeds
via
an
intermolecular
1,5-H
hydrogen
atom
transfer
imine
radical
intermediate.
This
approach
features
high
efficiency,
a
readily
available
catalyst
system,
and
broad
functional
group
tolerance.
Chemical Science,
Journal Year:
2024,
Volume and Issue:
15(20), P. 7502 - 7514
Published: Jan. 1, 2024
The
exploitation
of
new
reactive
species
and
novel
transformation
modes
for
their
synthetic
applications
have
significantly
promoted
the
development
organic
methodology,
drug
discovery,
advanced
functional
materials.
α-Iminyl
radical
cations,
a
class
distonic
ions,
exhibit
great
potential
synthesis
valuable
molecules.
For
generation,
conjugate
addition
to
α,β-unsaturated
iminium
ions
represents
concise
yet
highly
challenging
route,
because
A
synergistic
I2/secondary
amine
catalysis
has
been
developed
for
the
modular
assembly
of
2,2'-bipyridines,
employing
oxime
esters
and
enals
as
readily
available
starting
materials.
This
method
demonstrates
a
good
substrate
scope
functional
group
tolerance
can
easily
afford
series
structurally
new
2,2'-bipyridines
in
moderate
to
yields.
Advanced Synthesis & Catalysis,
Journal Year:
2023,
Volume and Issue:
365(21), P. 3690 - 3703
Published: Sept. 16, 2023
Abstract
A
multifaceted
study
on
the
effect
of
various
factors
efficiency
photocyclization
naphthofuran
O‐acyl
oximes
was
performed.
It
showed
that
without
any
additives
or
in
presence
electron
acceptors,
reaction
occurs
by
a
radical
pathway
and
with
low
chemoselectivity,
while
DABCO
promotes
intramolecular
cyclization
to
give
naphthofuroquinolines
(NFQs)
34–87%
yields.
The
iminyl
formed
under
UV
irradiation
due
single
transfer
(SET)
N−O
bond
cleavage
undergoes
selective
homolytic
aromatic
substitution
(HAS)
formation
new
C−N
bond.
This
route
quinoline‐annulated
scaffolds
is
based
use
both
as
an
agent
proton
acceptor.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(41), P. 8741 - 8746
Published: Oct. 10, 2024
An
iron-catalyzed
relay
annulation
protocol
was
disclosed,
which
utilizes
oxime
esters
and
4-hydroxycoumarins
as
the
readily
available
starting
materials
showcases
broad
substrate
scope
good
functional
group
tolerance.
This
method
allows
simultaneous
generation
of
two
C-C
one
C-O
bonds
rings
in
step,
affording
structurally
new
furocoumarins
moderate
to
yields.
Journal of the American Society for Mass Spectrometry,
Journal Year:
2024,
Volume and Issue:
35(5), P. 951 - 959
Published: April 10, 2024
C-H
bond
ortho-substitution
reaction
has
always
been
a
significant
and
challenging
topic
in
organic
chemistry.
We
proposed
synthesis
method
based
on
microwave
plasma
torches.
High-resolution
mass
spectrometry
was
used
to
monitor
rapid
products.
2-Alkylbenzimidazole
can
be
formed
through
the
of
phenylnitrenium
ion
nitriles
millisecond
scale.
This
achieve
one-step
formation
benzimidazoles
from
benzene
ring
single-substituted
compounds
without
addition
external
oxidants
or
catalysts.
A
similar
activation
accomplished
with
ketones.
Meanwhile,
reactor
modified,
resulting
2-methylbenzimidazole
successfully
collected,
indicating
device
good
application
potential
reactions
such
as
reaction.
Organic & Biomolecular Chemistry,
Journal Year:
2024,
Volume and Issue:
22(36), P. 7316 - 7320
Published: Jan. 1, 2024
A
facile
and
practical
protocol
to
construct
2
H
-imidazoles
by
applying
an
oxime
acetate
block
as
the
sole
component
via
homo/cross-coupling
catalyzed
Cu(
i
)
was
developed.
