The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(5), P. 3509 - 3524
Published: Feb. 16, 2024
A
photocatalytic
annulation
cascade
of
unactivated
N-alkene-linked
indoles
with
Langlois'
reagent
by
a
radical
relay
is
developed
at
room
temperature
under
blue
LED
irradiation.
The
reaction
afforded
series
tri/difluoromethylated
pyrrolo[1,2-a]indoles
in
moderate
to
good
yields.
DFT
study
suggests
that
the
ascribed
rhodamine
6G-induced
cyclization
involving
vinyl
addition-radical
and
hydrogen-atom-abstraction
(HAA)
processes,
interestingly,
are
applied
as
fluorescent
dyes
into
fluorescence
spectrum
live-cell
imaging.
This
paper
represents
an
initial
example
on
cascades
HAA
process.
Advanced Materials,
Journal Year:
2024,
Volume and Issue:
36(25)
Published: March 18, 2024
Abstract
Petroleum,
as
the
“lifeblood”
of
industrial
development,
is
important
energy
source
and
raw
material.
The
selective
transformation
petroleum
into
high‐end
chemicals
great
significance,
but
still
exists
enormous
challenges.
Single‐atom
catalysts
(SACs)
with
100%
atom
utilization
homogeneous
active
sites,
promise
a
broad
application
in
petrochemical
processes.
Herein,
research
systematically
summarizes
recent
progress
SACs
catalytic
reaction,
proposes
role
structural
design
enhancing
performance,
elucidates
reaction
mechanisms
conversion
processes,
reveals
high
activity
origins
at
atomic
scale.
Finally,
key
challenges
are
summarized
an
outlook
on
design,
identification
appropriate
artificial
intelligence
technology
provided
for
achieving
scale‐up
process.
Angewandte Chemie International Edition,
Journal Year:
2024,
Volume and Issue:
63(41)
Published: July 18, 2024
Abstract
Although
highly
appealing
for
rapid
access
of
molecular
complexity,
multi‐functionalization
alkenes
that
allows
incorporation
more
than
two
functional
groups
remains
a
prominent
challenge.
Herein,
we
report
novel
strategy
merges
dipolar
cycloaddition
with
photoredox
promoted
radical
ring‐opening
remote
C(sp
3
)−H
functionalization,
thus
enabling
smooth
1,2,5‐trifunctionalization
unactivated
alkenes.
A
regioselective
[3+2]
anchors
reaction
trigger
onto
alkene
substrates.
The
subsequent
halogen
atom
transfer
(XAT)
selectively
initiates
process,
which
is
followed
by
series
1,5‐hydrogen
(1,5‐HAT)
and
intermolecular
fluorine
(FAT)
events.
With
this
method,
site‐selective
introduction
three
different
accomplished
broad
spectrum
valuable
β‐hydroxyl‐ϵ‐fluoro‐nitrile
products
are
synthesized
from
readily
available
terminal
The Journal of Organic Chemistry,
Journal Year:
2023,
Volume and Issue:
89(1), P. 474 - 483
Published: Dec. 14, 2023
A
radical
1,2,4-trifunctional
reaction
of
thiosulfonate
to
unactivated
olefin
is
achieved
by
a
migration
strategy
under
mild
conditions.
In
this
reaction,
the
more
unstable
primary
free
radicals
are
in
situ
generated
after
heteroaryl
groups
presence
DABCO.
This
trifunctionalization
olefins
involves
two
C–S
bond
formations
and
one
C–C
formation.
Organic Letters,
Journal Year:
2023,
Volume and Issue:
25(49), P. 8814 - 8818
Published: Dec. 6, 2023
This
work
demonstrates
sulfonyl
group-induced
remote
C(sp3)–N
bond
construction
using
a
strategy
of
merging
aryl
radical-mediated
halogen
atom
transfer
and
intramolecularly
regioselective
hydrogen
(HAT).
A
plethora
aliphatic
sulfones,
sulfonamides,
sulfonates
are
amenable
undergo
C(sp3)–H
amination
by
utilizing
an
iron
salt
at
room
temperature.
protocol
involves
iodine
transfer,
HAT
process
enabled
alkyl
radical
adjacent
to
group,
mediated
diazonium
salt.
European Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
27(8)
Published: Jan. 20, 2024
Abstract
Regioselective
C(
sp
3
)−H
bond
functionalization
in
atom‐
and
step‐economic
mode
has
long
been
recognized
as
a
prominent
challenging
task
due
to
its
application
late‐stage
modification
of
complex
skeletons,
natural
products
drugs.
As
complement
transition
metal‐catalyzed
C−H
activation
carbene/nitrene
insertion
reactions,
hydrogen
atom
transfer
(HAT)
emerges
versatile
tool
for
showcases
significant
distinctive
superiority
terms
selectivity
trend
substrate
scope.
Intramolecular
HAT
processes
initiated
by
nitrogen‐
oxygen‐centered
radicals,
aryl
vinyl
have
already
well
developed
the
past
century.
In
contrast,
development
alkyl
radical‐mediated
reactions
lagged
behind,
although
generation
methods
corresponding
radicals
under
mild
conditions
gained
rapid
growth.
Especially,
selective
efficient
from
unactivated
radical
is
highly
their
comparable
BDEs
polarity.
This
Concept
highlights
recent
advance
regioselective
ubiquitous
bonds
enabled
intramolecular
H‐atom
radicals.
