The impact of earth-abundant metals as a replacement for Pd in cross coupling reactions
Chemical Science,
Journal Year:
2024,
Volume and Issue:
15(24), P. 9016 - 9025
Published: Jan. 1, 2024
Initial
calculations
of
environmental
footprints
associated
with
using
Ni
vs
Pd
catalysis
in
a
representative
metal-catalyzed
Suzuki–Miyaura
cross-coupling
reveal
that
the
choice
ligated
metal
is
often
NOT
consequence.
Rather,
it
culmination
other
parameters
such
as
medium.
Language: Английский
On the role of surfactants: rethinking “aqueous” chemistry
Green Chemistry,
Journal Year:
2023,
Volume and Issue:
26(2), P. 739 - 752
Published: Dec. 11, 2023
Some
of
the
latest
technological
developments
involving
chemistry
in
water
are
discussed.
Language: Английский
Nickel‐Catalyzed Hydro‐ and Deutero‐dehalogenations of (Hetero)Aryl Halides under Aqueous Micellar Catalysis Conditions
Monica S. Lopez Lemus,
No information about this author
Rahul D. Kavthe,
No information about this author
Rohan M. Thomas
No information about this author
et al.
ChemSusChem,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 24, 2025
Abstract
Efficient
Ni‐catalyzed
hydrodehalogenations
and
deuterodehalogenations
of
aryl/heteroaryl
halides
are
reported
herein.
This
new
technology
can
be
used
to
incorporate
not
only
hydrogen,
but
also
deuterium
into
various
aromatic/heteroaromatic
compounds
with
high
efficiency,
using
2–6
mol
%
nickel
in
the
presence
stoichiometric
NaBH
4
.
Over
40
examples
have
been
successfully
converted
corresponding
(hetero)arenes
excellent
yields.
The
process
is
conducted
under
green
chemistry
conditions:
water
enabled
by
designer
surfactants,
a
medium
which
readily
recycled.
Minimal
organic
solvent,
needed
given
small
(academic)
scale
reactions,
for
product
isolation,
resulting
low
E‐Factors.
Additionally,
sterically
hindered
substrates
amenable,
as
selected
APIs
that
feature
carbon‐fluorine
bonds.
Language: Английский
A Telescopic, Scalable and Industrially Feasible Method for the Synthesis of Antidepressant Drug, Moclobemide
Helvetica Chimica Acta,
Journal Year:
2024,
Volume and Issue:
107(9)
Published: July 16, 2024
Abstract
An
improved,
scalable,
industrially
feasible
telescopic
process
for
multigram
synthesis
of
highly
commercialized
antidepressant
drug,
moclobemide
has
been
developed.
Unlike
the
conventional
approaches,
this
enjoys
privilege
being
an
economical,
operationally
simple,
effectively
and
quantitative
method
amide‐containing
drug
moclobemide,
showcasing
easy
isolation
purification
without
aid
column
chromatography.
environmentally
benign
reagent
combination
TBN
NHS
very
converts
acyl
source,
4‐chlorobenzaldehyde
into
its
N
‐hydroxysuccinimide
ester
intermediate,
which
simply
affords
molecule
after
nucleophilic
substitution
with
amine
source.
The
synthetic
successfully
scaled‐up
upto
~145
g
scale
75
%
overall
yield
>95
first
crop
HPLC
purity.
Language: Английский
1-Iodoglycal: A Versatile Intermediate for the Synthesis of d-Glyco Amides and Esters Employing Carbonylative Cross-Coupling Reaction
ACS Omega,
Journal Year:
2024,
Volume and Issue:
9(29), P. 31732 - 31744
Published: July 11, 2024
In
this
study,
we
present
the
development
of
two
catalytic
processes:
a
Pd-PEPPSI-catalyzed
aminocarbonylation
and
Pd(OAc)
Language: Английский
Copper-catalysed bromine atom transfer cyclisation in SDS micelles
Shuoren Wu,
No information about this author
Xue Yang,
No information about this author
Zhou Jianlin
No information about this author
et al.
Chemical Communications,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
SDS
micelles
have
a
remarkable
beneficial
effect
on
the
copper-mediated
atom
transfer
radical
cyclisation
of
non-activated
alkyl
bromides
in
water.
Language: Английский