Cited by Copper-catalysed bromine atom transfer cyclisation in SDS micelles

The impact of earth-abundant metals as a replacement for Pd in cross coupling reactions DOI

Michael U. Luescher, Fabrice Gallou, Bruce H. Lipshutz

et al.

Chemical Science, Journal Year: 2024, Volume and Issue: 15(24), P. 9016 - 9025

Published: Jan. 1, 2024

Initial calculations of environmental footprints associated with using Ni vs Pd catalysis in a representative metal-catalyzed Suzuki–Miyaura cross-coupling reveal that the choice ligated metal is often NOT consequence. Rather, it culmination other parameters such as medium.

Language: Английский

Citations

On the role of surfactants: rethinking “aqueous” chemistry DOI

Bruce H. Lipshutz

Green Chemistry, Journal Year: 2023, Volume and Issue: 26(2), P. 739 - 752

Published: Dec. 11, 2023

Some of the latest technological developments involving chemistry in water are discussed.

Language: Английский

Citations

Nickel‐Catalyzed Hydro‐ and Deutero‐dehalogenations of (Hetero)Aryl Halides under Aqueous Micellar Catalysis Conditions DOI

Monica S. Lopez Lemus,

Rahul D. Kavthe,

Rohan M. Thomas

et al.

ChemSusChem, Journal Year: 2025, Volume and Issue: unknown

Published: April 24, 2025

Abstract Efficient Ni‐catalyzed hydrodehalogenations and deuterodehalogenations of aryl/heteroaryl halides are reported herein. This new technology can be used to incorporate not only hydrogen, but also deuterium into various aromatic/heteroaromatic compounds with high efficiency, using 2–6 mol % nickel in the presence stoichiometric NaBH 4 . Over 40 examples have been successfully converted corresponding (hetero)arenes excellent yields. The process is conducted under green chemistry conditions: water enabled by designer surfactants, a medium which readily recycled. Minimal organic solvent, needed given small (academic) scale reactions, for product isolation, resulting low E‐Factors. Additionally, sterically hindered substrates amenable, as selected APIs that feature carbon‐fluorine bonds.

Language: Английский

Citations

1-Iodoglycal: A Versatile Intermediate for the Synthesis of d-Glyco Amides and Esters Employing Carbonylative Cross-Coupling Reaction DOI

Milene M. Hornink, Mônica F. Z. J. Toledo, Daniel C. Pimenta

et al.

ACS Omega, Journal Year: 2024, Volume and Issue: 9(29), P. 31732 - 31744

Published: July 11, 2024

In this study, we present the development of two catalytic processes: a Pd-PEPPSI-catalyzed aminocarbonylation and Pd(OAc)

Language: Английский

Citations

A Telescopic, Scalable and Industrially Feasible Method for the Synthesis of Antidepressant Drug, Moclobemide DOI

Anup Kumar Keshri, Anjali Gupta,

Upma Gulati

et al.

Helvetica Chimica Acta, Journal Year: 2024, Volume and Issue: 107(9)

Published: July 16, 2024

Abstract An improved, scalable, industrially feasible telescopic process for multigram synthesis of highly commercialized antidepressant drug, moclobemide has been developed. Unlike the conventional approaches, this enjoys privilege being an economical, operationally simple, effectively and quantitative method amide‐containing drug moclobemide, showcasing easy isolation purification without aid column chromatography. environmentally benign reagent combination TBN NHS very converts acyl source, 4‐chlorobenzaldehyde into its N ‐hydroxysuccinimide ester intermediate, which simply affords molecule after nucleophilic substitution with amine source. The synthetic successfully scaled‐up upto ~145 g scale 75 % overall yield >95 first crop HPLC purity.

Language: Английский

Citations

Copper-catalysed bromine atom transfer cyclisation in SDS micelles DOI

Shuoren Wu,

Xue Yang,

Zhou Jianlin

et al.

Chemical Communications, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

SDS micelles have a remarkable beneficial effect on the copper-mediated atom transfer radical cyclisation of non-activated alkyl bromides in water.

Language: Английский

Citations