Navigating Electrochemical Oxidative Functionalization of Olefins: Selected Mechanistic and Synthetic Examples

Chemical Communications, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

This highlight presents curated examples illustrating diverse electrochemical olefin functionalization strategies, including direct, mediated, and catalytic approaches, offering a concise overview of this rapidly evolving field.

Language: Английский

---

Progress on Cobalt-Catalyzed C(sp²)—H Activation for the Construction of Nitrogen-Containing Benzo Heterocycles

Chinese Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: 45(2), P. 655 - 655

Published: Jan. 1, 2025

Language: Английский

---

Multiple Atropo Selectivity by κ²‐N,O‐Oxazoline Urea Ligands in Cobaltaelectro‐Catalyzed C─H Activations: Decoding Selectivity with Data Science Integration

ChemistryEurope, Journal Year: 2025, Volume and Issue: unknown

Published: April 8, 2025

Enantioselective catalysis is one of the most prominent strategies in organic synthesis to access chiral bioactive compounds and advanced materials. Particularly, development ligands has significantly efficiency selectivity transition metal‐catalyzed enantioselective transformations. Over recent decades, numerous ligand classes with distinct geometrical electronic properties have been established. Despite these advances, demand for novel, tunable, highly effective persists, driven by need structurally diverse molecules pursuit greener, more sustainable catalytic processes. Herein, a novel class oxazoline ureas introduced their potential as κ 2 ‐ N , O ‐preligands metal demonstrated. The urea are featurized compared amide enol derivatives using physical descriptors. A multivariate linear regression model constructed quantitatively describe effect quinoline fragment from substrate on enantioselectivity. Moreover, effectively applied atropo‐enantioselective cobaltaelectro‐catalyzed C─H annulations 1‐alkynyl indoles.

Language: Английский

---

Nickel-electrocatalyzed enantioselective C–H activations for chemo-divergence

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 16, 2024

Abstract Enantioselective electrocatalysis bears unique potential for the sustainable assembly of enantiomerically enriched molecules 1–7 . This approach allows electro-oxidative C–H activation to be performed paired hydrogen evolution reaction 8,9 While recent progress featured scarce transition metals with limited availability 10–17 , we, herein, reveal that Earth-abundant 3d transition-metal nickel is characterized by performance, while having high natural abundance 18 and reduced toxicity 19 Thereby, electrocatalytic enabled enantioselective desymmetrizations bicyclic alkenes, leading three-dimensional molecular building blocks multiple stereogenic elements 20 Here, ligand optimization was guided smart feature analysis enantioselectivity enhancement. The detailed mechanistic investigation experimental studies organometallic intermediates in conjunction computational identified key features design including non-covalent interactions 21,22 guarantee full selectivity control.

Language: Английский

---

Advances in Asymmetric Electrochemical Synthesis

Chinese Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 44(3), P. 673 - 673

Published: Jan. 1, 2024

Language: Английский

---