Nickel‐Cobalt Bimetallic Strategy Enables Regioselective C8–H Alkylation of Polyaromatics with Inert Alkyl Chlorides

Chinese Journal of Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 11, 2025

Comprehensive Summary A regioselective C8−H alkylation of polyaromatics exampled with inert alkyl chloride is reported. The reaction proceeds via the synergistic participation inexpensive transition metals nickel and cobalt. This approach enables coupling various substituted polyaromatic rings a broad range primary secondary chlorides. Further synthetic applications provide series simple conversions to useful building blocks, suggesting its potency in late‐stage functionalization complex molecules. Mechanistic investigation illustrates that goes through radical process an unusual Ni(II)→Ni(III)→Ni(I) cycle being responsible for rate‐determining C−H insertion radicals, which are generated by homolysis chloroalkane 2‐electrons oxidative addition Co(I).

Language: Английский

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3-Halo-5,6-dihydro-4H-1,2-oxazine N-oxides as synthetic equivalents of unsaturated nitrile oxides in the [3 + 2]-cycloaddition with arynes: synthesis of substituted 3-vinyl-1,2-benzisoxazoles

Organic & Biomolecular Chemistry, Journal Year: 2024, Volume and Issue: 22(18), P. 3615 - 3621

Published: Jan. 1, 2024

The reaction of 3-halo-5,6-dihydro-4

Language: Английский

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Recent Advances in Nonprecious Metal Catalysis

Organic Process Research & Development, Journal Year: 2024, Volume and Issue: 28(9), P. 3524 - 3544

Published: Aug. 9, 2024

Developing catalytic reactions using nonprecious-metal to achieve various synthetic transformations remains a valuable pursuit the scientific community. As part of continuing review series that is published within precompetitive chemistry alliance between AbbVie, Boehringer Ingelheim and Pfizer, this article underscores wide-ranging uses Cu-, Co-, Fe-, Ni-catalysis. The significant uptick in NPMC-related publications signifies escalating curiosity among researchers investigate advance capabilities these metals.

Language: Английский

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Expedient C–H allylation of sulfoxonium ylides: merging C–H and C–C/C–het bond activation

Chemical Communications, Journal Year: 2023, Volume and Issue: 59(95), P. 14173 - 14176

Published: Jan. 1, 2023

Sulfoxonium ylide chelation-assisted C-H allylation of arenes has been accomplished utilizing strained vinyl carbo/heterocycles as the allyl surrogates via sequential and C-C/het bond activation. Broad substrate scope, Co-catalysis, selectivity, late-stage drug mutation are important practical features.

Language: Английский

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Palladium‐Catalyzed Amide Directed Regioselective γ‐Alkenylation of Unactivated Alkenes with Vinylcyclopropanes

European Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 27(42)

Published: Aug. 7, 2024

Abstract Herein, we have demonstrated a palladium‐catalyzed γ‐alkenylation of unactivated alkenes with vinylcyclopropanes. A bidentate 8‐aminoquinoline directing group was utilized for the regioselective γ‐C(alkenyl)−H functionalization This protocol exhibits wide substrate scope and good selectivity. Additionally, diversification performed to demonstrate synthetic utility protocol. Mechanistic investigations were carried out provide an insight reaction mechanism. plausible mechanism also proposed present methodology.

Language: Английский

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Synthesis of Cobalt Complexes and Study of Their Catalytic Activities in Various Organic Transformations

Springer proceedings in physics, Journal Year: 2024, Volume and Issue: unknown, P. 87 - 108

Published: Dec. 28, 2024

Language: Английский

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