Published: Jan. 1, 2024
Language: Английский
Nature Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: March 11, 2025
Language: Английский
Citations
1
ChemCatChem, Journal Year: 2024, Volume and Issue: 16(15)
Published: March 15, 2024
Abstract Low‐valent chromium catalysts are cheap and less toxic compared to other transition metal catalysts. Here in, we reported a ligand‐free chromium(III)‐catalyzed manganese reductive cross‐coupling of unactivated alkyl electrophiles, such as sulfonates chlorides, with trisulfide dioxides thiolation agents form carbon−sulfur bonds. The powerful method featured ample substrate scope wide functional group tolerance, constructing large number unsymmetrical disulfides under simple conditions.
Language: Английский
Citations
7
ACS Catalysis, Journal Year: 2024, Volume and Issue: 14(9), P. 6432 - 6439
Published: April 11, 2024
Herein, we disclose a nickel-catalyzed dearomative reductive aryl-fluoroalkenylation of indoles by defluorinative coupling with gem-difluoroalkenes. The catalytic protocol affords facile assembly various monofluoroalkene-containing polycyclic fused indolines bearing two contiguous carbon stereocenters in high diastereo- and enantioselectivities tolerance diverse functional groups.
Language: Английский
Citations
6
ACS Catalysis, Journal Year: 2024, Volume and Issue: 14(3), P. 1575 - 1583
Published: Jan. 16, 2024
The example of iron-catalyzed reductive fluoroalkylalkenylation unactivated alkenes has been disclosed, affording the stereodefined homoallylic fluoroalkanes with high efficiency and regioselectivity. This three-component cross-electrophile coupling features directing groups free, good functional group tolerance, broad substrate scope, late-stage difunctionalization biorelevant molecules. Moreover, this protocol sheds light on distinct reactivity disparities between fluoroalkyl nonfluoroalkyl radicals in cross-coupling reactions, highlighting unique nature iron/B2pin2 systems.
Language: Английский
Citations
5
The Chemical Record, Journal Year: 2024, Volume and Issue: unknown
Published: Sept. 17, 2024
Abstract The transition metal catalyzed coupling reaction has revolutionized the strategies for forging carbon‐carbon bonds. In contrast to traditional cross‐coupling methods using pre‐prepared nucleophilic organometallic reagents, reductive reactions C−C bonds formation provide some advantages. Because both partners are reduced in final products a stoichiometric amount of reductant, this approach not only avoids need use sensitive species, but also provides an orthogonal and complementary access classical reaction. Notably, feature readily available fragments, promote good step economy, exhibit high functional group tolerance unique chemoselectivity, which have propelled their increasingly popular organic synthesis. recent years, due low price, minimal toxicity, environmentally benign character, iron‐catalyzed garnered significant attention from synthetic chemists pharmacologists, especially coupling. This review aims insightful overview advances reactions, illustrate possible mechanisms.
Language: Английский
Citations
5
Science China Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 3, 2025
Language: Английский
Citations
0
ACS Catalysis, Journal Year: 2025, Volume and Issue: unknown, P. 7700 - 7709
Published: April 24, 2025
Language: Английский
Citations
0
The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown
Published: May 14, 2025
Thianthrenium salts have emerged as one of the most versatile reagents, gaining significant popularity within synthetic community for their utility in construction C-C and C-X (X = N, O, S, P, halogens) bonds. The use photoredox transition metal catalysis with thianthrenium C-heteroatom bond formation is well established. However, these methods require elevated temperatures, expensive catalysts, ligands under stringent conditions effective execution. In contrast, photocatalysis- transition-metal-free approaches constructing bonds using salt derivatives become increasingly sought after. this regard, electron-donor-acceptor (EDA)-complex reactions a powerful strategy organic synthesis, eliminating need photocatalysts visible light irradiation. EDA-complex photochemistry exploits electron-acceptor properties salts, facilitating rapid generation radical intermediates via C-S cleavage. These play pivotal role enabling variety valuable formations. Perspective, we highlight advances EDA-complex-mediated involving mechanisms, substrate scope, limitations For sake brevity, article organized into five main sections: (1) Nitrogen-based donor reactions, (2) Oxygen-based (3) Sulfur-based (4) Phosphorus-based (5) π-based focus on C-C, C-S, C-B C-P
Language: Английский
Citations
0
Advanced Science, Journal Year: 2024, Volume and Issue: 11(32)
Published: July 4, 2024
Abstract The transition metal‐catalyzed multi‐component cross‐electrophile sulfonylation, which incorporates SO 2 as a linker within organic frameworks, has proven to be powerful, efficient, and cost‐effective means of synthesizing challenging alkyl–alkyl sulfones. Transition metal catalysts play crucial role in this method by transferring electrons from reductants electrophilic organohalides, thereby causing undesirable side reactions such homocoupling, protodehalogenation, β ‐hydride elimination, etc. It is worth noting that tertiary alkyl halides have rarely been demonstrated compatible with current methods owing various undesired reactions. In work, zinc‐promoted sulfonylation developed through radical‐polar crossover pathway. This approach enables the synthesis sulfones, including 1°‐1°, 2°‐1°, 3°‐1°, 2°‐2°, 3°‐2° types, inexpensive readily available halides. Various functional groups are well tolerated resulting yields up 93%. Additionally, protocol successfully applied intramolecular homo‐sulfonylation insights gained work shall useful for further development access
Language: Английский
Citations
2
The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 89(17), P. 12001 - 12009
Published: Aug. 15, 2024
Herein, we present a Ni-catalyzed direct cross-coupling of heteroaromatic thioethers with aryl iodides via selective C(sp2)–S bond cleavage under reductive conditions, thereby providing various biaryl frameworks high efficiency. Mechanistic studies suggested Mo(CO)6 played crucial role in facilitating the activation bond. This protocol demonstrated wide substrate scope, operational simplicity, and good functional group compatibility. Furthermore, utility this reaction was highlighted by facile scale-up sequential modification heteroaryl frameworks.
Language: Английский
Citations
2