N‐Heterocyclic Carbene Catalyzed Reactions Involving Acetylenic Breslow and/or Acylazolium as Key Intermediates DOI Open Access

Yujie He,

Jintao Chen, Yu Jiang

et al.

The Chemical Record, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 19, 2024

N-heterocyclic carbene (NHC) organocatalysis has been developed as a powerful tool in modern synthetic chemistry. NHC catalytic activation of ynals and alkynoic acid derivatives provided versatile reactions that involve acetylenic Breslow and/or acylazolium key intermediates, diverse transformations have established for access to molecules with unique skeletons efficient fashions. Herein we summarize the recent achievements NHC-catalyzed involving intermediates. Different belonging three modes, including (1) conjugate additions derived α,β-unsaturated (2) β-umpolung via (3) are emphasized examples plausible mechanisms cited guide better understanding.

Language: Английский

N‐Heterocyclic Carbene Catalyzed Reactions Involving Acetylenic Breslow and/or Acylazolium as Key Intermediates DOI Open Access

Yujie He,

Jintao Chen, Yu Jiang

et al.

The Chemical Record, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 19, 2024

N-heterocyclic carbene (NHC) organocatalysis has been developed as a powerful tool in modern synthetic chemistry. NHC catalytic activation of ynals and alkynoic acid derivatives provided versatile reactions that involve acetylenic Breslow and/or acylazolium key intermediates, diverse transformations have established for access to molecules with unique skeletons efficient fashions. Herein we summarize the recent achievements NHC-catalyzed involving intermediates. Different belonging three modes, including (1) conjugate additions derived α,β-unsaturated (2) β-umpolung via (3) are emphasized examples plausible mechanisms cited guide better understanding.

Language: Английский

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