The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Nov. 30, 2024
A
catalyst-free
photoinduced
deconstructive
fluorosulfonylation
cascade
of
spiro
dihydroquinazolinones
with
DABSO
and
NFSI
is
reported.
This
protocol
features
mild
reaction
conditions,
good
yields
excellent
functional
group
tolerance,
providing
a
practical
approach
to
the
quinazolin-4(1H)-one-functionalized
aliphatic
sulfonyl
fluorides.
In
addition,
ease
gram-scale
synthesis
versatility
SuFEx
exchange
highlight
application
potential
this
protocol.
Green Chemistry,
Journal Year:
2024,
Volume and Issue:
26(6), P. 3435 - 3440
Published: Jan. 1, 2024
A
practical
electrosynthesis
of
aryl
sulfonyl
fluorides
from
nitroarenes
is
described.
Cheap
N
-methylimidazolium
p
-toluenesulfonate
has
been
found
to
be
an
effective
additive,
promoting
the
desired
fluorosulfonylation
under
very
mild
conditions.
European Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
27(23)
Published: May 25, 2024
Abstract
Sulfonyl
fluorides
have
widespread
applications
in
many
fields,
including
organic
synthesis,
chemical
biology,
drug
discovery
and
materials
science.
In
particular,
the
past
decade,
a
number
of
aliphatic
sulfonyl
been
identified
showing
various
biological
activities.
These
appealing
features
brought
about
significant
advancement
developing
synthetic
methods
to
access
fluorides.
this
review,
we
will
discuss
recent
developments
radical
approaches
for
synthesis
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(15), P. 3130 - 3134
Published: April 8, 2024
Isoxazolines
and
isoxazoles
commonly
serve
as
core
structures
of
many
therapeutic
agents
natural
products.
However,
the
metal-free
catalysis-free
strategy
for
synthesis
these
privileged
motifs
at
room
temperature
remains
a
challenging
task.
Herein,
we
report
three-component
to
afford
diverse
isoxazolines
via
[3
+
2]
cycloadditions
in
situ-formed
nitronates
olefins/alkynes
under
visible-light
irradiation.
Chemical Reviews,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 22, 2025
Fluorine
and
nitrogen
form
a
successful
partnership
in
organic
synthesis,
medicinal
chemistry,
material
sciences.
Although
fluorine-nitrogen
chemistry
has
long
rich
history,
this
field
received
increasing
interest
made
remarkable
progress
over
the
past
two
decades,
driven
by
recent
advancements
transition
metal
organocatalysis
photochemistry.
This
review,
emphasizing
contributions
from
2015
to
2023,
aims
update
state
of
art
synthesis
applications
nitrogen-based
organofluorine
functional
molecules
chemistry.
In
dedicated
sections,
we
first
focus
on
fluorine-containing
reagents
organized
according
type
groups
attached
nitrogen,
including
N-F,
N-RF,
N-SRF,
N-ORF.
review
also
covers
nitrogen-linked
building
blocks,
catalysts,
pharmaceuticals,
agrochemicals,
underlining
these
components'
broad
applicability
growing
importance
modern
Chinese Journal of Chemistry,
Journal Year:
2024,
Volume and Issue:
42(18), P. 2203 - 2210
Published: May 14, 2024
Comprehensive
Summary
Compared
to
well‐established
1,5‐HAT
of
N
‐centered
radicals,
the
synthetic
applications
1,2‐HAT
process
were
scarce
due
high
barrier
and
constrained
three‐membered
transition
state.
Here,
we
have
developed
a
novel
C(sp
3
)‐H
gem
‐difluoroallylation
via
base
assisted
formal
amidyl
radicals
with
reductive
quenching
cycle
photocatalyst.
This
transformation
enables
efficient
formation
α‐aminoalkyl
showcases
good
functional
group
tolerance.
Our
preliminary
mechanistic
experiments,
along
Density
Functional
Theory
(DFT)
calculations
demonstrate
feasibility
especially
when
by
base.
Furthermore,
our
method
also
succeeds
in
Giese
addition
electron‐deficient
alkenes
as
well
styrene.
Synlett,
Journal Year:
2024,
Volume and Issue:
unknown
Published: June 24, 2024
Abstract
Numerous
reports
invoke
CuIII–F
intermediates
engaging
in
oxidative
cross-couplings
mediated
by
low/mid-valent
copper
and
formal
sources
of
‘F+’
oxidants.
These
elusive
typically
instable
CuIII
fluorides
have
been
rarely
characterized
or
spectroscopically
identified,
making
their
existence
participation
within
catalytic
cycles
somehow
questionable.
We
authenticated
a
stable
organocopper(III)
fluoride
that
undergoes
Csp–CF3
bond
formation
upon
addition
silyl-capped
alkynes
following
2
e–
CuIII/CuI
redox
shuttle.
This
finding
strongly
supports
the
intermediacy
C–C
coupling.
review
herein
state
art
about
well-defined
enabling
cross-coupling
reactions.
1
Introduction
Brief
History
Coupling-Competent
Fluorides
3
Design
an
Isolable
–
yet
Reactive
Organocopper(III)
Fluoride
4
Alkyne
Trifluoromethylation:
Scope
Mechanism
5
Extension
to
Aryl–CF3
C–Heteroatom
Couplings
6
Summary
Outlook
