Recent Advances in Asymmetric Addition Reactions to Isatins DOI
Ke Xie, Ao Li, Zhichao Chen

et al.

Synthesis, Journal Year: 2024, Volume and Issue: unknown

Published: July 30, 2024

Abstract The 3-substituted-3-hydroxy-2-oxindole scaffolds are not only widely encountered in bioactive compounds but also serve as versatile building blocks for the construction of diverse valuable architectures. Although numerous synthetic methodologies have been developed over past decades, asymmetric addition nucleophiles or their equivalents to isatin substrates has proved be one most efficient strategies synthesis chiral 3-substituted-3-hydroxy-2-oxindoles. This Short Review aims summarize significant progress achieved this field recent years, with particular attention paid reaction development, mechanism, and stereo-induction models. 1 Introduction 2 Asymmetric Alkylation Isatins 3 Alkenylation Dienylation 4 Alkynylation 5 Allenylation 6 Arylation 7 Annulations 8 Conclusions Outlooks

Language: Английский

Recent Advances in Asymmetric Addition Reactions to Isatins DOI
Ke Xie, Ao Li, Zhichao Chen

et al.

Synthesis, Journal Year: 2024, Volume and Issue: unknown

Published: July 30, 2024

Abstract The 3-substituted-3-hydroxy-2-oxindole scaffolds are not only widely encountered in bioactive compounds but also serve as versatile building blocks for the construction of diverse valuable architectures. Although numerous synthetic methodologies have been developed over past decades, asymmetric addition nucleophiles or their equivalents to isatin substrates has proved be one most efficient strategies synthesis chiral 3-substituted-3-hydroxy-2-oxindoles. This Short Review aims summarize significant progress achieved this field recent years, with particular attention paid reaction development, mechanism, and stereo-induction models. 1 Introduction 2 Asymmetric Alkylation Isatins 3 Alkenylation Dienylation 4 Alkynylation 5 Allenylation 6 Arylation 7 Annulations 8 Conclusions Outlooks

Language: Английский

Citations

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