Nickel-Catalyzed Branched Hydroalkylation of Alkenes with Diazo Compounds DOI

Nikita Kvasovs,

Valeriia Iziumchenko, Alistair J. Sterling

et al.

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

A nickel-catalyzed, branched-selective hydroalkylation of alkenes using diazo compounds has been developed. This protocol enables the functionalization both activated and unactivated alkenes, in directed nondirected manners. Mono-, di-, trisubstituted can be effectively transformed. Highly diastereoselective hydroalkylations have also demonstrated. The method provides a novel approach for introducing an α-carbonyl moiety to which is currently inaccessible by existing methods. Preliminary mechanistic investigations suggest carbene-type mechanism, unusual nickel catalysis.

Language: Английский

Structure Matters: Tailored Graphitization of Carbon Dots Enhances Photocatalytic Performance DOI Creative Commons
Laura Morbiato, Lucía Cardo, Elisa Sturabotti

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 22, 2025

The chemical structure and photoredox properties of carbon dots (CDs) are not yet fully understood. However, it has been reported that, by carefully choosing the starting materials tuning their synthesis conditions, is possible to obtain CDs with different structures therefore photocatalytic performance. For this work, a family was synthesized in Milli-Q water via microwave-assisted protocol, using citric acid urea as precursors. syntheses were carried out at times temperatures assess impact synthetic parameters on final materials. After extensive accurate purification, abilities selected subset tested performing photocatalyzed atom transfer radical addition reaction. Among CDs, best ones found be those highest temperature, which most graphitic. A number characterization techniques then used evaluate degree graphitization elucidate origin

Language: Английский

Citations

4
The Cascade Reaction Chemistry of Diazo Compounds with Intentionally Designed Alkene to Access Esterified Heterocycles DOI

Shi-Cui Fang,

Shao-Qun Cai,

Panpan Li

et al.

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

Exploration of the cascade reactivity diazo compounds with alkenes is a challenging and largely unmet goal. Herein, we disclose light-mediated de novo synthesis esterified heterocycles under mild conditions. The reaction displays broad functional group tolerance, including wide variety alkenes, compounds, some bioactive molecules. Importantly, synthetic appeal was demonstrated for synthesizing indoleamine 2,3-dioxygenase inhibitor analogue, deethylated derivative natural product leucomidine C, anti-inflammatory agent AN669.

Language: Английский

Citations

0
Organophotocatalytic Redox-Neutral Strategy for Late-Stage Drug Functionalization with SO2 Gas DOI Creative Commons
Paramita Datta, Subir Maji,

Prativa Biswas

et al.

Chemical Science, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

We report here a metal-free, redox-neutral photocatalytic strategy of SO 2 gas functionalization resulting in the one-pot synthesis sulfonamides, sulfonate esters, and thiosulfonates through photoexcited phenalenyl (PLY) ligand.

Language: Английский

Citations

0
Nickel-Catalyzed Branched Hydroalkylation of Alkenes with Diazo Compounds DOI

Nikita Kvasovs,

Valeriia Iziumchenko, Alistair J. Sterling

et al.

Journal of the American Chemical Society, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 25, 2025

A nickel-catalyzed, branched-selective hydroalkylation of alkenes using diazo compounds has been developed. This protocol enables the functionalization both activated and unactivated alkenes, in directed nondirected manners. Mono-, di-, trisubstituted can be effectively transformed. Highly diastereoselective hydroalkylations have also demonstrated. The method provides a novel approach for introducing an α-carbonyl moiety to which is currently inaccessible by existing methods. Preliminary mechanistic investigations suggest carbene-type mechanism, unusual nickel catalysis.

Language: Английский

Citations

0