Site Specific C3‐Alkenylation of Indoles Mediated by in situ C‐H Iodination DOI
Yongli Zhao,

Dingsheng Cao,

Jie‐Ping Wan

et al.

Asian Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 29, 2024

Abstract The C3‐alkenylation of indoles have been developed by means a novel in situ iodination tactic which is capable mediating the Heck coupling with alkenes. method features specific site‐selectivity oriented C−I bond, high‐step efficiency without pre‐functionalization for C‐halogen bond construction, as well highly general tolerance to different terminal alkenes, including unactivated acrylates, acrylic acid, vinyl sulfone functionalized natural products.

Language: Английский

Iron-Catalyzed Oxidative Rearrangement of Cyclopropanone Hemiaminals: General Access to Pyrroloindolones from Indoles DOI
Roger Machín Rivera,

Zack R. Ferrin,

Vincent N. G. Lindsay

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: 26(22), P. 4738 - 4743

Published: May 29, 2024

A concise synthetic approach to medicinally relevant pyrroloindolones and related fused heterocycles is reported via the diastereoselective

Language: Английский

Citations

3
Unconventional Ligand‐to‐Catalyst Ratio for the Distal C−C Bond Formation via C−H Activation and Chain‐Walking DOI

King Hung Nigel Tang,

Haluhi Takahashi,

Ryo Tokutake

et al.

Advanced Synthesis & Catalysis, Journal Year: 2024, Volume and Issue: 366(17), P. 3610 - 3615

Published: July 2, 2024

Abstract A mechanism‐navigated enantioselective alkylation of an indole C2 C−H bond with internal alkene was developed. Under the unconventional ligand‐to‐metal catalyst ratio, a moderate enantiomeric ratio (er), ranging from 70:30 to 88:12, achieved our original ligand. We propose that chain‐walking and formation are mechanistically independent suggest hydridoiridium generated source does not play role in process.

Language: Английский

Citations

0
Rh(III)-Catalyzed Chemoselective [4 + 2] Annulations for the Synthesis of [1,3]Oxazinoindolones: A Combined Experimental and Computational Study DOI
Perla Bharath Kumar,

Chittala Emmaniel Raju,

Saikat Roy

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 4, 2024

The interaction of

Language: Английский

Citations

0
Phosphine‐mediated one‐pot reactions: Syntheses of β‐acylated alkylidene indandiones and furo[2,3‐f]dibenzotropones via MBH‐type annulation/acylation or Wittig reaction DOI
Po‐Chung Chien,

You‐Jie Chen,

Gangababu Marri

et al.

Journal of the Chinese Chemical Society, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 7, 2024

Abstract Phosphine‐mediated one‐pot reactions have been developed that involve two mechanistically distinct assembled in one reaction vessel via the sequential addition process. The first step involves MBH‐type annulation of α , β ‐ynones to afford cyclic products each case, which then engages subsequent ‐acylation or intramolecular Wittig reactions. conditions are mild and efficient, providing acylated alkylidene indandiones 70%–99% yields furo[2,3‐ f ]dibenzotropones 65%–91% yields, respectively.

Language: Английский

Citations

0
Site Specific C3‐Alkenylation of Indoles Mediated by in situ C‐H Iodination DOI
Yongli Zhao,

Dingsheng Cao,

Jie‐Ping Wan

et al.

Asian Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 29, 2024

Abstract The C3‐alkenylation of indoles have been developed by means a novel in situ iodination tactic which is capable mediating the Heck coupling with alkenes. method features specific site‐selectivity oriented C−I bond, high‐step efficiency without pre‐functionalization for C‐halogen bond construction, as well highly general tolerance to different terminal alkenes, including unactivated acrylates, acrylic acid, vinyl sulfone functionalized natural products.

Language: Английский

Citations

0