Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Aug. 20, 2024
Abstract
Herein
we
have
developed
a
heterogeneous
catalyst
for
synthesizing
various
anticancer
and
antidiabetic
derivatives
via
heterocyclic
synthesis
under
solvent-free
conditions
at
mild
temperatures.
This
approach
eliminates
the
need
complex
cleanup
or
column
chromatography,
thus
minimizing
waste
production.
Moreover,
can
be
recovered
reused
up
to
multiple
times
without
compromising
product
yields,
demonstrating
its
sustainability
environmental
friendliness.
Additionally,
evaluated
each
synthetic
derivative
activities.
Initial
assays
revealed
that
certain
exhibit
promising
inhibition
against
human
breast
cancer
cells
(MCF7),
suggesting
their
potential
as
lead
structures
future
agents.
Furthermore,
synthesized
were
assessed
activity,
showing
superior
efficacy.
Notably,
containing
–H,
–CH3,
–OCH3
substituents
demonstrated
excellent
activity
compared
5-fluorouracil
(5-FU),
while
–H
–Br
showed
notable
activities
over
acarbose,
highlighting
therapeutic
potential.
Thus,
our
study
presents
highly
effective
sustainable
polyhydroquinoline
derivatives,
emphasizing
catalyst's
dual
benefits
in
organic
medicinal
chemistry
applications.
New Journal of Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Jan. 1, 2024
In
this
article,
we
have
reported
the
conduction
of
an
N-heterocyclic
functional
2D
COF,
and
remarkable
catalytic
activity
towards
Knoevenagel
condensation
reaction
synthesis
γ
-butyrolactones
at
room
temperature.
