The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 11, 2024
A
catalyst-free
reductive
radical-polar
crossover
cyclization
with
alkenes
and
sodium
dithionite
to
construct
densely
functionalized
cyclic
sultines
was
described.
The
key
the
success
of
this
practical
protocol
relies
not
only
on
a
bifunctional
role
dithionite,
that
is,
serving
as
radical
initiator
SO
Advanced Science,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 25, 2025
Abstract
The
rapid
assembly
of
diverse
cyclic
amines
from
simple
precursors
is
now
considered
as
an
ideal
platform
with
respect
to
efficiency
and
sustainability.
To
date,
numerous
synthetic
methods
have
been
successfully
developed
however,
most
them
are
limited
a
narrow
subset
amines,
variations
in
ring
size
often
requiring
different
substrates
distinct
strategies.
Furthermore,
the
“escape‐from‐Flatland”
concept
has
led
chemists
focus
on
synthesis
C(sp
3
)‐rich
small
molecules
for
potential
drug
candidates.
Herein,
successful
realization
radical‐polar
crossover
bicyclization
reaction
reported
easily
available
cyclopropylamines
substituted
alkenes
through
photoredox
catalysis.
This
approach
introduces
innovative
methodology
de
novo
collection
4/5‐,
5/5‐,
6/5‐,7/5‐,
5/6‐fused
saturated
bicyclic
systematic
modular
manner
excellent
diastereoselectivity.
work
highlights
utility
photoinduced
radical–polar
bicyclization,
applicability
which
showcased
by
functional
group
tolerance,
wide
substrate
scopes,
derivatization
reactions.
Chemical Science,
Journal Year:
2024,
Volume and Issue:
15(28), P. 11092 - 11098
Published: Jan. 1, 2024
A
concise
protocol
for
the
synthesis
of
constrained
bicycloalkanes
has
been
developed,
using
easily
obtainable
α-silyl
alcohols
and
alkenes
through
a
bibase-promoted
brook
rearrangement/radical-polar
crossover
cyclization
(RPCC)
process.
Organic Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 9, 2025
Sulfone
motifs
play
important
roles
in
bioactive
compounds
and
functional
materials.
The
development
of
efficient
methodologies
for
constructing
sulfonyl-containing
has
thus
attracted
considerable
attention.
Here,
we
introduce
a
protocol
the
preparation
alkyl
aryl
sulfones
under
mild
conditions.
This
employs
β-thioamide
sulfone
as
novel
motif
donor.
It
forms
sulfinates
situ
basic
conditions,
which
then
undergo
cross-coupling
with
intermediates
that
were
generated
from
ligand-free
copper-catalyzed
cyclopropenes
(CPEs)
ring
opening.
Organic Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: May 7, 2025
Highly
functionalized
sulfone
containing
scaffolds
are
ubiquitous
and
attracting
increasing
interest
in
pharmaceutical
agrochemicals
owing
to
their
enhanced
activities.
Herein,
we
present
an
alternative
protocol
access
highly
substituted
sulfones
from
readily
accessible
olefin
feedstocks
sulfinate
salts
through
a
DABSO
enabled
anti-Markovnikov
hydrosulfonylation
process.
Notably,
the
practical
procedure
features
excellent
compatibility
with
various
susceptible
functional
groups
broad
substrate
scope
under
mild
operationally
simple
conditions.
Gram-scale
preparation,
post-functionalization
of
complex
molecules,
applications
synthesis
bioactive
compounds
underscore
potential
drug
discovery.
The Journal of Organic Chemistry,
Journal Year:
2024,
Volume and Issue:
89(17), P. 12619 - 12627
Published: Aug. 16, 2024
An
electrochemical
synthesis
of
vinyl,
alkyl,
and
allyl
sulfones
using
sodium
sulfinates
olefins
was
reported.
This
method
uses
direct
current
to
pass
through
an
undivided
cell
equipped
with
graphite
carbon
electrodes,
a
series
diverse
sulfone
compounds
can
be
synthesized
at
room
temperature
in
high
yields.
Organic Chemistry Frontiers,
Journal Year:
2024,
Volume and Issue:
11(22), P. 6340 - 6346
Published: Jan. 1, 2024
We
developed
the
first
transition-metal-catalyzed,
regiodivergent
sulfonylation
of
aziridines,
enabling
efficient
synthesis
diverse
β-amino
sulfones
under
mild
conditions
with
broad
substrate
compatibility
and
high
regioselectivity.
Organic Letters,
Journal Year:
2024,
Volume and Issue:
26(32), P. 6798 - 6802
Published: Aug. 7, 2024
Sulfur-containing
compounds
exhibit
potent
significance
in
drug
molecules.
Thiosulfonates
as
1,3-thiosulfonylation
reactants
to
olefins
have
yet
be
investigated.
Herein,
we
report
photoinduced
1,3-difunctionalization
of
β,γ-unsaturated
ketones
with
thiosulfonates,
which
undergo
a
radical
1,2-acyl
shift.
The
protocol
features
mild
conditions,
high
regioselectivity,
and
100%
atom
economy.
Chinese Journal of Chemistry,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 2, 2024
Comprehensive
Summary
Herein,
we
report
a
rare
example
of
three‐component
net‐oxidative
sulfonylation
SO
2
surrogate
with
an
oxidatively
activated
radical
precursor
under
mild
and
metal‐
external‐oxidant‐free
conditions.
The
mildness
sustainability
the
reaction
are
enabled
by
photoelectrocatalysis,
3‐aza‐1,5‐dienes,
organotrifluoroborates
1,4‐diazabicyclo[2.2.2]octane
bis(sulfur
dioxide)
adduct
(DABSO)
undergo
sulfonylative
cyclization
to
afford
sulfono
4‐pyrrolin‐2‐ones
in
atom‐economical
manner
broad
substrate
scope
good
functional‐group
tolerance.
protocol
is
amenable
late‐stage
diversification
complex
molecular
architectures
as
well
gram‐scale
synthesis.
Sunlight
could
be
used
light
source,
conducted
all‐solar
mode
using
commercially
available
photovoltaic
panel
generate
electricity
situ
.
Mechanistic
studies
reveal
that
generated
(DABCO),
which
was
generally
innocent
previous
reactions,
functions
electron
shuttle
between
photocatalytic
cycle
reactants.
Synlett,
Journal Year:
2024,
Volume and Issue:
unknown
Published: April 6, 2024
Abstract
Sulfur-containing
heterocycles,
where
the
S(R)
moiety
is
located
within
cyclic
structure,
have
found
tremendous
applications
in
fields
of
chemical,
pharmaceutical,
and
materials
sciences
due
to
their
unique
biological
pharmaceutical
activities.
Recent
years
witnessed
increasing
interest
sulfur-containing
new
methods
for
synthesis
been
reported
by
adopting
modern
methodologies
technologies
through
insertion
sulfur
dioxide.
The
main
objective
this
Account
overview
latest
major
developments
on
heterocyclic
systems,
mainly
covering
thermo-,
photo-
electron-induced
cyclization
dioxide
(SO2).
We
aim
provide
readership
with
a
comprehensive
understanding
topic
offer
positive
outlook
promising
future
field.
1
Introduction
2
Thermal-Induced
Cyclization
3
Photoinduced
Radical
4
Electron-Induced
5
Conclusion
RSC Advances,
Journal Year:
2024,
Volume and Issue:
14(21), P. 14697 - 14701
Published: Jan. 1, 2024
A
versatile
photoredox-catalyzed
three-component
sulfonylation
of
diaryliodonium
salts
with
DABSO
and
silyl
enolates
involving
the
insertion
SO2
was
developed.
Moreover,
by
employing
β-alkyl
substituted
as
substrates,
would
give
α-alkyl
β-keto
sulfones,
which
are
difficult
to
accessed
previous
method
SO2.