Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown
Published: July 9, 2024
Language: Английский
Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown
Published: July 9, 2024
Language: Английский
European Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: 27(23)
Published: May 25, 2024
Abstract Sulfonyl fluorides have widespread applications in many fields, including organic synthesis, chemical biology, drug discovery and materials science. In particular, the past decade, a number of aliphatic sulfonyl been identified showing various biological activities. These appealing features brought about significant advancement developing synthetic methods to access fluorides. this review, we will discuss recent developments radical approaches for synthesis
Language: Английский
Citations
12Nature Communications, Journal Year: 2025, Volume and Issue: 16(1)
Published: Jan. 2, 2025
Unsymmetric disulfides are prevalent in natural products and essential medicinal chemistry materials science, but their robust synthesis poses significant challenges. In this paper, we report an expeditous transition-metal-free methodology for synthesizing unsymmetric through the addition of perthiyl radicals to alkenes. This study marks use generating by reacting SO2 with unactivated alkyl (pseudo)halides (Cl/Br/I/OTs). Various primary, secondary tertiary substituted different functional groups successfully function as suitable reactants. The formation involvement reaction process verified mechanistic studies DFT calculations. Overall, method leverages readily available electrophiles alkenes alongside a single setup efficiently form both carbon-sulfur sulfur-sulfur bonds simultaneously. Here, authors novel transition-metalfree
Language: Английский
Citations
0Organic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 11(22), P. 6340 - 6346
Published: Jan. 1, 2024
We developed the first transition-metal-catalyzed, regiodivergent sulfonylation of aziridines, enabling efficient synthesis diverse β-amino sulfones under mild conditions with broad substrate compatibility and high regioselectivity.
Language: Английский
Citations
3Science China Chemistry, Journal Year: 2024, Volume and Issue: unknown
Published: Oct. 8, 2024
Language: Английский
Citations
3Synlett, Journal Year: 2024, Volume and Issue: unknown
Published: June 24, 2024
Abstract Numerous reports invoke CuIII–F intermediates engaging in oxidative cross-couplings mediated by low/mid-valent copper and formal sources of ‘F+’ oxidants. These elusive typically instable CuIII fluorides have been rarely characterized or spectroscopically identified, making their existence participation within catalytic cycles somehow questionable. We authenticated a stable organocopper(III) fluoride that undergoes Csp–CF3 bond formation upon addition silyl-capped alkynes following 2 e– CuIII/CuI redox shuttle. This finding strongly supports the intermediacy C–C coupling. review herein state art about well-defined enabling cross-coupling reactions. 1 Introduction Brief History Coupling-Competent Fluorides 3 Design an Isolable – yet Reactive Organocopper(III) Fluoride 4 Alkyne Trifluoromethylation: Scope Mechanism 5 Extension to Aryl–CF3 C–Heteroatom Couplings 6 Summary Outlook
Language: Английский
Citations
1Organic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 11(20), P. 5876 - 5883
Published: Jan. 1, 2024
A visible-light-induced copper-catalyzed regiodivergent sulfonylation of oxime esters with sodium sulfinates under mild conditions is reported, yielding a range useful β-ketosulfones and sulfonated pyrrolines convertible functional groups.
Language: Английский
Citations
1The Journal of Organic Chemistry, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 30, 2024
A catalyst-free photoinduced deconstructive fluorosulfonylation cascade of spiro dihydroquinazolinones with DABSO and NFSI is reported. This protocol features mild reaction conditions, good yields excellent functional group tolerance, providing a practical approach to the quinazolin-4(1H)-one-functionalized aliphatic sulfonyl fluorides. In addition, ease gram-scale synthesis versatility SuFEx exchange highlight application potential this protocol.
Language: Английский
Citations
1Chinese Chemical Letters, Journal Year: 2024, Volume and Issue: 35(9), P. 109986 - 109986
Published: May 10, 2024
Language: Английский
Citations
0Organic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 11(13), P. 3589 - 3595
Published: Jan. 1, 2024
This method offers a simple, effective pathway for synthesizing diverse β-keto sulfonamides with satisfactory yields under mild conditions, showing broad substrate compatibility and good tolerance towards various functional groups.
Language: Английский
Citations
0Organic Chemistry Frontiers, Journal Year: 2024, Volume and Issue: 11(17), P. 4740 - 4747
Published: Jan. 1, 2024
The Reppe sulfonylation reaction has remained substantially underexplored. We present a novel method for involving SO 2 insertion, remarkably without the need metal catalysts, instead utilizing Brønsted bases as catalysts.
Language: Английский
Citations
0