Collaborative Reduction-Induced Nickel-Catalytic Selective C–S Coupling of Aryl Di/Trithiosulfonates with Aryl Halides DOI
Lulu Liu, Jiaqi Hou, Yingying Ma

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 25, 2024

Metal-catalytic conversion of polysulfide reagents is a major challenge in organic synthesis due to its challenging activation modes multiple S–S bonds. The utilization aryl di- and trithiosulfonates nickel-catalyzed reductive coupling with halides has been unexplored. Herein, we unprecedentedly describe PPh3 Zn-collaborative reduction-induced nickel-catalytic selective C–S di/trithiosulfonates access sulfides over common disulfides or trisulfides. Diverse mechanistic studies indicate that the key design such reaction could be attributed employment MgCl2, which collaborate Zn for improved reduction potential enables cleavage PhSO2(S)naryl (n = 2, 3) electrophilic sulfur species sulfuration controllable fashion.

Language: Английский

Collaborative Reduction-Induced Nickel-Catalytic Selective C–S Coupling of Aryl Di/Trithiosulfonates with Aryl Halides DOI
Lulu Liu, Jiaqi Hou, Yingying Ma

et al.

Organic Letters, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 25, 2024

Metal-catalytic conversion of polysulfide reagents is a major challenge in organic synthesis due to its challenging activation modes multiple S–S bonds. The utilization aryl di- and trithiosulfonates nickel-catalyzed reductive coupling with halides has been unexplored. Herein, we unprecedentedly describe PPh3 Zn-collaborative reduction-induced nickel-catalytic selective C–S di/trithiosulfonates access sulfides over common disulfides or trisulfides. Diverse mechanistic studies indicate that the key design such reaction could be attributed employment MgCl2, which collaborate Zn for improved reduction potential enables cleavage PhSO2(S)naryl (n = 2, 3) electrophilic sulfur species sulfuration controllable fashion.

Language: Английский

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