Advances in the Synthesis of Cyclopropylamines

Chemical Reviews, Journal Year: 2025, Volume and Issue: unknown

Published: March 6, 2025

Cyclopropylamines are an important subclass of substituted cyclopropanes that combine the unique electronic and steric properties with presence a donor nitrogen atom. In addition to their in diverse array biologically active compounds, cyclopropylamines utilized as synthetic intermediates, particularly ring-opening or cycloaddition reactions. Consequently, synthesis these compounds has constituted significant research topic, evidenced by abundant published methods. widely used Curtius rearrangement, classical cyclopropanation methods have been adapted integrate function (Simmons-Smith reaction, metal-catalyzed reaction diazo on olefins, Michael-initiated ring-closure reactions) advances enantioselective synthesis. More recently, specific developed for preparation aminocyclopropane moiety (Kulinkovich reactions applied amides nitriles, cyclopropenes, involving C-H functionalization, ...). The topic this review is present different cyclopropylamine derivatives, aim covering methodological best possible, highlighting scope, stereochemical aspects future trends.

Language: Английский

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Ni/Cu Cocatalyzed Asymmetric Hydrogenation of Amino Ketones with Water as a Hydrogen Source

ACS Catalysis, Journal Year: 2025, Volume and Issue: unknown, P. 2666 - 2676

Published: Jan. 29, 2025

Language: Английский

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A Unified Strategy for the Synthesis of Diverse Bicyclo[2.2.2]octadiene Ligands

The Journal of Organic Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 19, 2025

A new approach for the enantioselective synthesis of various bicyclo[2.2.2]octadiene ligands has been developed, which features a chiral oxazaborolidinium-catalyzed asymmetric Diels-Alder reaction to construct bicyclo[2.2.2]octane framework. The pivotal ketone 12 served as common intermediate that was finally transformed into desired C1- and C2-symmetric dienes. This work provides an alternative method reported diene would be beneficial exploration potentials this type versatile ligand in transformations.

Language: Английский

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Preferred Electric Field Mechanism for Frustrated Lewis Pair Reactivity

ChemPhysChem, Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 6, 2024

This study employs computational methods to investigate the mechanism of H

Language: Английский

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