Recent trends in the identification and engineering of halogenases DOI Creative Commons
Huibin Wang, Ikuro Abe

Tetrahedron Chem, Journal Year: 2024, Volume and Issue: unknown, P. 100112 - 100112

Published: Nov. 1, 2024

Language: Английский

Sequential oxidation of L-lysine by a non-heme iron hydroxylase DOI Creative Commons

Edward S. Reynolds,

Thomas G. Smith, Anoop R. Damodaran

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 28, 2025

2-oxoglutarate-dependent non-heme iron hydroxylases offer a direct route to functionalizing C( sp 3 )–H bonds across diverse range of substrates, making them prime candidates for chemoenzymatic synthetic strategies. We demonstrate the ability L-lysine dioxygenase perform sequential oxidation and computationally explore structural elements that promote this reactivity.

Language: Английский

Citations

0
Recent trends in the identification and engineering of halogenases DOI Creative Commons
Huibin Wang, Ikuro Abe

Tetrahedron Chem, Journal Year: 2024, Volume and Issue: unknown, P. 100112 - 100112

Published: Nov. 1, 2024

Language: Английский

Citations

0