Research on transition metals for the multicomponent synthesis of benzo-fused γ-lactams
Fadhil Faez Sead,
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Vicky Jain,
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Suhas Ballal
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et al.
RSC Advances,
Journal Year:
2025,
Volume and Issue:
15(4), P. 2334 - 2346
Published: Jan. 1, 2025
Benzo-fused
γ-lactams
are
fundamental
in
medicinal
chemistry,
acting
as
essential
elements
for
various
therapeutic
agents
due
to
their
structural
adaptability
and
capability
enhance
biological
activity.
Language: Английский
Palladium-Catalyzed Site-Selective C–H Sulfonylation via Aryl Thianthrenium Salts to Access Diarylsulfones
Chunjie Ni,
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Jinping Liu,
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Xiaoxu Zhang
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et al.
The Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Feb. 21, 2025
We
presented
a
highly
efficient
palladium-catalyzed
site-selective
C-H
sulfonylation
reaction
via
aryl
thianthrenium
salts.
By
utilizing
readily
available
and
cost-effective
arenes
along
with
sodium
sulfinates,
we
achieved
the
C(sp2)-S
cross-coupling
high
efficiency,
establishing
dependable
method
for
synthesizing
diarylsulfones
satisfactory
yields.
This
exhibits
excellent
tolerance
toward
functional
groups,
scalability,
synthesis
or
late-stage
functionalization
of
bioactive
molecules,
making
it
valuable
tool
drug
modifications.
Language: Английский
Palladium/Norbornene Cooperative Catalysis 2-Fold C–H/C–X Coupling: Construction of Polycyclic Aromatic Hydrocarbons from Brominated Benzimidazoles
Ming‐Xuan Wang,
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Yi‐Ming Li,
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Wei Zeng
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et al.
Organic Letters,
Journal Year:
2025,
Volume and Issue:
unknown
Published: March 10, 2025
A
palladium/norbornene
(NBE)-catalyzed
2-fold
C-H/C-X
coupling
reaction
of
aryl
iodides
is
reported.
Bromine-substituted
benzimidazoles
were
chosen
as
electrophilic
and
termination
reagents,
the
versatile
polycyclic
aromatic
hydrocarbon
products
successfully
obtained.
The
strategy
overcomes
challenge
catalyst
poisoning
by
heterocyclic
substrates.
In
addition,
imidazole
moiety
in
product
endowed
with
a
localization
role,
thus
enabling
compounds
to
be
applied
wider
synthetic
scenario,
fluorescence
persisted.
Furthermore,
bioactivity
evaluation
has
identified
three
promising
leading
3b,
4e,
4i.
Language: Английский
Pd/NBE-Catalyzed One-Pot Modular Synthesis of Tetrahydro-γ-carbolines
Cuifeng Huang,
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Wenlin Zhang,
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Ying Liu
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et al.
The Journal of Organic Chemistry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 14, 2025
Tetrahydro-γ-carbolines
are
especially
outstanding
fused
heterocyclic
ring
systems
possessing
significant
biological
activities
in
the
central
nervous
system.
Here,
using
commercially
available
NBE
derivatives
(NBEs),
we
report
an
efficient
protocol
for
one-pot
modular
synthesis
of
4-substituted
tetrahydro-γ-carbolines
via
Catellani/aza-Michael
addition
cascade
from
easily
3-iodo-1-tosyl-1H-indole,
aziridines
and
olefins.
This
approach
exhibits
a
wide
substrate
scope,
good
yields,
scalability,
potential
extension
toward
Mebhydroline
analogues.
Language: Английский