One-Pot Domino Catalysis to Construct Alkyl/Aryl Pyrroles Initiated by Pd-TMM Annulation of Unactivated Imines

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 9, 2025

Herein, a one-pot domino catalyzed three-component process is described, which initiated by palladium/zinc cooperatively cycloaddition between trimethylenemethane (TMM) and unactivated alkyl/aryl imines, followed isomerization Zn(OTf)2-catalyzed DDQ oxidation, furnishing valuable substituted pyrroles. We disclose that the cooperative catalysis affords dual-Zn(OTf)2-stabilized azapalladacycle, wherein Pd–N bond polarized Zn(OTf)2, facilitating unique outer-sphere allylic amination. Moreover, subsequent dehydrogenation can be feasibly promoted zinc catalysis.

Language: Английский

Synthesis of polysubstituted spiroazepines via [4 + 3] annulation reaction of ninhydrin-derived Morita−Baylis−Hillman carbonates with 1‑heterodienes

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 141478 - 141478

Published: Jan. 1, 2025

Language: Английский