Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: May 2, 2025

An asymmetric catalytic Pudovik addition/[1,2]-phospha-Brook rearrangement/allylation reaction of readily available isatins, phosphites, and vinyl ethylene carbonate enabled by a chiral iridium catalyst was developed in one-pot fashion. A wide range enantioenriched oxindole derivatives containing two adjacent stereocenters could be obtained good to high yields with excellent diastereoselectivity enantioselectivity (65-99% yield, 7:1 >20:1 dr, generally 99% ee). This cascade protocol owned the advantages starting materials, regio-/diastereo-/enantioselectivity, substrate scope generality.

Language: Английский