Photocatalytic Direct Borylation of Benzothiazole Heterocycles via a Triplet Activation Strategy DOI

Ze‐Le Chen,

Claire Empel, Yang Xie

et al.

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 11, 2025

Boron compounds are widely employed in organic chemistry, pharmaceuticals, and materials science. Among them, borylated heterocycles serve as versatile synthons for the construction of new C-C or C-heteroatom bonds via coupling radical processes. Such methods direct C-H borylation reactions high synthetic value to reduce number steps amount waste improve efficiency. Despite significant advances, remains an ongoing challenge with great potential applications chemical synthesis. Herein, we describe a photocatalytic reaction five-membered ring by employing stable N-heterocyclic carbene borane borylating reagent photoredox catalyst. Under green mild conditions, was achieved on series benzo-fused heterocyclic compounds. Further studies demonstrate utility this approach pharmaceutical agrochemical research.

Language: Английский

Photocatalytic Direct Borylation of Benzothiazole Heterocycles via a Triplet Activation Strategy DOI

Ze‐Le Chen,

Claire Empel, Yang Xie

et al.

Organic Letters, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 11, 2025

Boron compounds are widely employed in organic chemistry, pharmaceuticals, and materials science. Among them, borylated heterocycles serve as versatile synthons for the construction of new C-C or C-heteroatom bonds via coupling radical processes. Such methods direct C-H borylation reactions high synthetic value to reduce number steps amount waste improve efficiency. Despite significant advances, remains an ongoing challenge with great potential applications chemical synthesis. Herein, we describe a photocatalytic reaction five-membered ring by employing stable N-heterocyclic carbene borane borylating reagent photoredox catalyst. Under green mild conditions, was achieved on series benzo-fused heterocyclic compounds. Further studies demonstrate utility this approach pharmaceutical agrochemical research.

Language: Английский

Citations

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